2017
DOI: 10.1177/1744806917709201
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Potentiation of NMDA receptor-mediated synaptic transmission at the parabrachial-central amygdala synapses by CGRP in mice

Abstract: The capsular part of the central amygdala (CeC) is called the “nociceptive amygdala,” as it receives nociceptive information from various pathways, including monosynaptic input from the lateral part of the parabrachial nucleus (LPB), a major target of ascending neurons in the spinal and medullary dorsal horn. LPB-CeC synaptic transmission is mediated by glutamate but the fibers from the LPB also contain calcitonin gene-related peptide (CGRP) and the CeC is rich in CGRP-binding sites. CGRP might be released in … Show more

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Cited by 37 publications
(30 citation statements)
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“…Thus, one interesting possibility is that CGRP modulates synaptic transmission via different mechanisms with a different time course, such that CGRP causes postsynaptic modification when applied acutely, while presynaptic modification occurs via long‐term effect. Recently, we found that exogenous application of CGRP also modulates NMDA receptor‐mediated EPSCs in a PKA‐dependent manner (Okutsu et al ., ), further supporting the notion of acute CGRP effects on postsynaptic mechanisms.…”
Section: Discussionsupporting
confidence: 68%
“…Thus, one interesting possibility is that CGRP modulates synaptic transmission via different mechanisms with a different time course, such that CGRP causes postsynaptic modification when applied acutely, while presynaptic modification occurs via long‐term effect. Recently, we found that exogenous application of CGRP also modulates NMDA receptor‐mediated EPSCs in a PKA‐dependent manner (Okutsu et al ., ), further supporting the notion of acute CGRP effects on postsynaptic mechanisms.…”
Section: Discussionsupporting
confidence: 68%
“…The calcium-stimulated AC1 is critical for CGRP induced potentiation and downstream protein kinase PKA is also required independent for the role of CGRP in the IC. Interestingly, in the amygdala, Okutsu et al reported that CGRP enhanced NMDAR-mediated excitatory potentials [36]. It is likely that CGRP may affect excitatory synapses differently in various brain regions.…”
Section: Innervation and Distribution Of Cgrp In The Icmentioning
confidence: 99%
“…We found that CGRP induced potentiation is NMDAR independent for the role of CGRP in the IC. Interestingly, in the amygdala, Okutsu et al reported that CGRP enhanced NMDARmediated excitatory potentials [36]. It is likely that CGRP may affect excitatory synapses differently in various brain regions.…”
Section: Modulation Of Synaptic Transmission By Cgrp In the Icmentioning
confidence: 99%