Potentiation of the Antibiotic Activity by the Essential Oils of Eugenia brasiliensis Lam. and Piper mosenii C. DC.

Abstract

The present study aimed to investigate the antibiotic-enhancing activity of the essential oils obtained from the leaves of Eugenia brasiliensis Lam (EOEb) and Piper mosenii C. DC. (EOPm) against multiresistant strains of Escherichia coli 06 and Staphylococcus aureus 10. The essential oils were obtained by hydrodistillation, and the minimum inhibitory concentrations (MIC) were determined through the broth microdilution method. The EOEb enhanced the activities of norfloxacin and erythromycin against Staphylococcus aureus and Escherichia coli, respectively. At the same conditions, the EOPm was found to potentiate the effects of gentamicin and erythromycin against E. coli. Of note, this is the first study to date that has reported the ability of these extracts to enhance the antibacterial activity of conventional antibiotics.

Emerging berries from the Brazilian Amazon and Atlantic Forest biomes: new sources of bioactive compounds with potential health benefits

“…[169][170][171] Additionally, frequent studies have shown that the leaves' essential oils have antibacterial activity. 32,[172][173][174] On the other side, growing evidence indicates that the fruit's versatile bioactive composition, mostly its anthocyanin and ellagitannin contents, is associated antiinflammatory activities in vitro. Grumixama's chemical attributes, sometimes unique to most fruits, hold a great potential to be used against non-communicable diseases in vivo.…”

“…No specific compound quantification has been conducted in yellow grumixama, but given its total carotenoid content, 142 it can be supposed that at least a few of the fruit's carotenoids would be classified as high or very high. On the other side, according to the chromatogram identification of Silva et al , 32 dark-colored grumixama can be classified as having low to moderate levels of specific carotenoids.…”

“…24 Both contain sesquiterpenes, which have health-promoting effects. [25][26][27][28][29][30][31][32] This collection of fruits has been linked to numerous functional properties, 16,17,23,24 which will be extensively explored in this study. Hence, the focus of this review was to highlight the berries native to the Brazilian Amazon and Atlantic Forest as promising sources of bioactive compounds, emphasizing their health-promoting effects in vitro and in vivo.…”