Potentiometric sensors based on surface molecular imprinting: Detection of cancer biomarkers and viruses

Wang, Yan Tian; Zhang, Zhiquan; Jain, Vijay Kumar; Yi, Jinju; Mueller, Steffen; Sokolov, Jonathan; Liu, Zhenxian; Levón, Kalle; Rigas, Basil; Rafailovich, Miriam

doi:10.1016/j.snb.2010.02.032

Cited by 168 publications

(80 citation statements)

References 45 publications

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“…Molecular imprinting techniques are not limited to MIP; molecularly imprinted SAM can be prepared by forming SAM in the presence of target compounds. Based on this strategy, CEA-imprinted SAMs have been prepared on the surface of electrodes [125]. The electrode potential of the CEA-imprinted SAM electrode shifts in the presence of 2.5–250 ng·mL −1 of CEA, whereas no response is observed to hemoglobin as a non-target protein.…”

Section: Mip-based Sensorsmentioning

confidence: 99%

Recent Progress in Electrochemical Biosensors for Glycoproteins

Akiba

Anzai

2016

Sensors

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This review provides an overview of recent progress in the development of electrochemical biosensors for glycoproteins. Electrochemical glycoprotein sensors are constructed by combining metal and carbon electrodes with glycoprotein-selective binding elements including antibodies, lectin, phenylboronic acid and molecularly imprinted polymers. A recent trend in the preparation of glycoprotein sensors is the successful use of nanomaterials such as graphene, carbon nanotube, and metal nanoparticles. These nanomaterials are extremely useful for improving the sensitivity of glycoprotein sensors. This review focuses mainly on the protocols for the preparation of glycoprotein sensors and the materials used. Recent improvements in glycoprotein sensors are discussed by grouping the sensors into several categories based on the materials used as recognition elements.

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Section: Mip-based Sensorsmentioning

confidence: 99%

Recent Progress in Electrochemical Biosensors for Glycoproteins

Akiba

Anzai

2016

Sensors

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“…Human rhino virus 14 imprinted MIP nanoparticles formulated with poly(vinylpyrrolidone-co-methacrylic acid) and cross-linked with N,N'-(1,2-dihydroxyethylene)-bisacrylamide (DHEBA) was immobilized on a 10 MHz quartz crystal microbalance (QCM) and these pronounced good sensor responses. Wang et al (2010) reported potentiometric sensors based on surface molecular imprinting for detection of poliovirus; however, the reported lower detection limit of the method 4000 virons mL -1 which is quite on higher side. One of the reasons for low sensitivity of sensors would be due to difficulty in migration of high molecular weight viron particles onto the sensing material which is imprinted with specific virus.…”

Section: Introductionmentioning

confidence: 97%

Polythiophene nanofilms for sensitive fluorescence detection of viruses in drinking water

Wankar

Turner

Krupadam

2016

Biosensors and Bioelectronics

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. showed that the nanofilm responds to TNV within 2 minutes; and cross-selectivity studies with tobacco mosaic virus (TMV) showed an excellent specificity for the targeted TNV.These binding experiments demonstrate the potential of fluorescence emission for the specific, label free and rapid detection of viruses using nanofilm sensors. Taking into account the lower limit of detection, the fluorescence sensing reported here is reliable, simple to perform, rapid, cost-effective and offers a sensitive analytical method for virus detection in water resources.2

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“…Binding sites with molecular recognition properties are formed after removing template molecules from the polymer, leaving behind cavities complementary in size and shape to the template for the subsequent rebinding process. Nowadays, MIPs are of growing interest for their potential applications as artificial enzymes [33], advanced materials for solid-phase extraction [34], thin coatings for sensor devices [35] and for determination of drugs [36,37], small analytes [38], peptides [39], proteins [40][41][42][43], and cancer biomarkers and viruses [44]. So, nanoparticles were used for selectivity enhancement to improve the cavity accessibility in MIP layer on the electrode surface.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of electrochemical sensor based on molecularly imprinted polymer and nanoparticles for determination trace amounts of morphine

Rezaei

Foroughi-Dehnavi

Ensafi

2015

Ionics

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A simple and rapid electrochemical method developed for the detection of trace amounts of morphine (MO) at the surface of modified pencil graphite electrode (PGE) with multiwall carbon nanotubes (MWCNTs), molecularly imprinted polymer (MIP), and gold nanoparticles (AuNPs).Various types of electrochemical methods containing cyclic voltammetry (CV), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS) were employed to probe the characteristics of the constructed electrode toward morphine. After optimization of several effective parameters, the calibration curve by SWV was linear in two linear domains, over the range of 0.008 to 5 μmol L −1 vs. Ag/AgCl, and the detection limit was 2.9 nM. The relative standard deviation (RSD) for six replicate determinations of 0.05 μmol L −1 MO was found to be 2.57 % (S/N = 3). Finally, the ability of the electrochemical sensor was successfully applied for MO determination in real samples such as human urine and plasma.

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Potentiometric sensors based on surface molecular imprinting: Detection of cancer biomarkers and viruses

Cited by 168 publications

References 45 publications

Recent Progress in Electrochemical Biosensors for Glycoproteins

Recent Progress in Electrochemical Biosensors for Glycoproteins

Polythiophene nanofilms for sensitive fluorescence detection of viruses in drinking water

Fabrication of electrochemical sensor based on molecularly imprinted polymer and nanoparticles for determination trace amounts of morphine

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