Potocytosis

Modeling Kinetics of Subcellular Disposition of Chemicals

“…Lastly, the formation of vesicles functioning as depots for temporary sequestration, without an immediate intracellular release, were observed for acetylcholine and several proteins. (1020)…”

Structure and function of endothelial caveolae

“…An alternate theory is proposed by Anderson et al, which postulates caveolae as a membrane system that occurs in all cell types and equivalents of lipid rafts are called caveola-like domains (Anderson, 1998). All endocytic activity mediated by caveolae is gathered under the term of potocytosis by which there are four possible fates for molecules and receptors internalized by caveolae: (1) receptors recycle and the ligand is delivered to the cytoplasm (e.g., 5-methyltetrahydrofolate, iron, calcium, water, and retinol); (2) receptors recycle and the ligand is delivered to the ER or other organelles (e.g., cholesterol, SV40 virus, advanced glycation end-product, CD59, basic fibroblast growth factor, autocrine motility factor, cholera toxin, and growth hormone); (3) both the ligand and the receptor are transported to the opposite surface of the cell: albumin, transthyretin, thrombomodulin, various plasma proteins, and water; (4) the receptor and ligand are internalized and held sequestered until both are returned to the cell surface: alkaline phosphatase, gp114, bradykinin, acetylcholine cholecystokinin, and endothelin (Mineo and Anderson, 2001, and references therein).…”

A computational investigation of cardiac caveolae as a source of persistent sodium current

“…It is well-established that caveolae are not merely static structural features of the cell membrane. One widely held view of caveolar function is that caveolae provide a clathrin-independent endocytic mechanism (Mineo and Anderson, 2001; Pelkmans and Helenius, 2002), so a kiss-and-run model of caveolar dynamics has been proposed (Pelkmans and Zerial, 2005) in which caveolae cycle between a transport vesicle state and a fused plasmalemmal invagination state. Indeed, such a mechanism is reported by Kozera et al (2009) who show that incubation of the rat ventricular myocyte in a hypertonic solution results in significant (and reversible) increases in sarcolemmal surface density of caveolar necks, presumably from some intracellular store of caveolar vesicles.…”