Real-time communication has witnessed a dramatic increase in recent years in user daily usage. In this domain, Session Initiation Protocol (SIP) is a well-known protocol found to provide trusted services (voice or video) to end users along with efficiency, scalability, and interoperability. Just like other Internet technology, SIP stores its related data in databases with a predefined data structure. In recent, SIP technologies have adopted the real advantages of in-memory databases as cache systems to ensure fast database operations during real-time communication. Meanwhile, in industry, there are several names of in-memory databases that have been implemented with different structures (e.g., query types, data structure, persistency, and key/value size). However, there are limited resources and poor recommendations on how to select a proper in-memory database in SIP communications. This paper provides recommended and efficient in-memory databases which are most fitted to SIP servers by evaluating three types of databases including Memcache, Redis, and Local (OpenSIPS built-in). The evaluation has been conducted based on the experimental performance of the impact of in-memory operations (store and fetch) against the SIP server by applying heavy load traffic through different scenarios. To sum up, evaluation results show that the Local database consumed less memory compared to Memcached and Redis for read and write operations. While persistency was considered, Memcache is the preferable database selection due to its 25.20 KB/s for throughput and 0.763 s of call–response time.