Power Doppler ultrasound, but not low‐field magnetic resonance imaging, predicts relapse and radiographic disease progression in rheumatoid arthritis patients with low levels of disease activity

Foltz, Violaine; Gandjbakhch, Frédérique; Etchepare, Fabien; Rosenberg, Carole; Tanguy, Marie Laure; Rozenberg, Sylvie; Bourgeois, Pierre; Fautrel, Bruno

doi:10.1002/art.33312

Cited by 206 publications

(136 citation statements)

References 41 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Inoue et al found DAS28-CRP 2.3 matched DAS28-ESR remission in Japanese patients [10].The present study suggests that composite scores overestimate remission and patients retain subclinical inflammation found on MRI. Our results join the various studies that have proven the dissociation between clinical remission according different composite scores and remission in imaging either by ultrasound (Ramirez J et al [11]) or MRI (Gandjbakhch F et al [12]) or both (Foltz V et al [13]). …”

Section: M6 P Referencessupporting

confidence: 59%

The MRI Features in Patients with Rheumatoid Arthritis Treated with Tocilizumab, in Clinical Remission or Low Disease Activity State

Rostom¹,

Hajjaj-Hassouni²

2015

J Clin Trials

View full text Add to dashboard Cite

Background: Subclinical inflammation and radiographic progression have been described in rheumatoid arthritis (RA) patients whose disease are in remission or are showing a low level of activity. The aim of this study was to evaluate in patients with rheumatoid arthritis RA in clinical remission or low disease activity (LDA) using composites scores, the synovitis and the bone oedema using MRI by OMERACT RAMRIS score (RAMRIS bone oedema and synovitis RAMRIS).

show abstract

Section: M6 P Referencessupporting

confidence: 59%

The MRI Features in Patients with Rheumatoid Arthritis Treated with Tocilizumab, in Clinical Remission or Low Disease Activity State

Rostom¹,

Hajjaj-Hassouni²

2015

J Clin Trials

View full text Add to dashboard Cite

show abstract

“…Therefore, a direct causal relation between clinically inflamed synovitis and structural damage progression seems unclear (11). However, the predictive value of subclinical synovitis, assessed by US or MRI, on structural damage has been suggested in RA patients treated with tumor necrosis factor blockers (21) and for patients in clinical remission (22).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Interleukin‐6 Level as a Surrogate Marker of Synovial Inflammation and as a Factor of Structural Progression in Early Rheumatoid Arthritis: Results From a French National Multicenter Cohort

Baillet¹,

Gossec

Paternotte

et al. 2015

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. Interleukin-6 (IL-6) is a key cytokine in rheumatoid arthritis pathogenesis. We aimed to analyze the association between IL-6 serum levels and joint inflammation at baseline and the correlation of time-integrated IL-6 values with structural damage during the first 36 months of early arthritis. Methods. IL-6 was assessed by 2 different methods in 813 patients of the French early arthritis cohort ESPOIR (Etude et Suivi des Polyarthrites Indiff erenci ees R ecentes) over 36 months. IL-6 and C-reactive protein (CRP) changes were correlated to radiographic progression assessed by the total Sharp/van der Heijde score (SHS). Synovium inflammation was assessed in a subgroup of 126 patients by ultrasonography (US). The relationship between SHS change and IL-6 or CRP levels at baseline was investigated by a univariate regression and a multivariable analysis. A longitudinal model nested by visit and patient was conducted to assess the role of IL-6 on SHS at each visit. Results. At baseline, IL-6 was more strongly correlated with the swollen joint count than CRP level. In the univariate analysis, the time-integrated value of IL-6 was more strongly correlated with the swollen joint count and the variation of SHS than timeintegrated CRP level. Baseline IL-6 was not independently associated with SHS change. Longitudinal models nested by patient showed that IL-6 levels were associated with structural damage independently from the Disease Activity Score in 28 joints, smoking status, rheumatoid factor, and anti-citrullinated protein peptide antibody serology, treatments, and CRP levels. Conclusion. IL-6 level was a marker of US synovitis at baseline. Repeated measurements of IL-6 are associated with structural damage.

show abstract

“…US is widely used in the early diagnosis of RA, particularly in the introduction and application of high frequency color Doppler US, which can monitor joint effusion, blood flow change in the synovium and synovial thickening (25). Furthermore, US may be used to monitor disease status and predict disease recurrence, providing an effective and valuable evaluation of treatments (26). Furthermore, US is more acceptable for patients, as it is relatively simple, cheap and does not use radiation (4).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of high-frequency ultrasound and magnetic resonance imaging in early rheumatoid arthritis

Wang

Sun

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Early diagnosis and management improve the outcome of patients with rheumatoid arthritis (RA). The present study explored the application of high-frequency ultrasound (US) and magnetic resonance imaging (MRI) in the detection of early RA. Thirty-nine patients (20 males and 19 females) diagnosed with early RA were enrolled in the study. A total of 1,248 positions, including 858 hand joints and 390 tendons, were examined by high-frequency US and MRI to evaluate the presence of bone erosion, bone marrow edema (BME), synovial proliferation, joint effusion, tendinitis and tendon sheath edema. The imaging results of the above abnormalities, detected by US, were compared with those identified using MRI. No statistically significant overall changes were observed between high-frequency US and MRI in detecting bone erosion [44 (5.1%) vs. 35 (4.1%), respectively; P>0.05], tendinitis [18 (4.6%) vs. 14 (1.5%), respectively; P>0.05] and tendon sheath edema [37 (9.5%) vs. 30 (7.7%), respectively; P>0.05]. Significant differences were observed between high-frequency US and MRI with regards to the detection of synovial proliferation [132 (15.4%) vs. 66 (7.7%), respectively; P<0.05] and joint effusion [89 (10.4%) vs. 52 (6.1%), respectively; P<0.05]. In addition, significant differences were identified between the detection of BME using MRI compared with high-frequency US (5.5 vs. 0%, respectively; P<0.05). MRI and high-frequency US of the dominant hand and wrist joints were comparably sensitive to bone erosion, tendinitis and tendon sheath edema. However, MRI was more sensitive in detecting bone marrow edema in early RA, while US was more sensitive in the evaluation of joint effusion and synovial proliferation. In conclusion, US and MRI are promising for the detection and diagnosis of inflammatory activity in patients with RA.

show abstract

Power Doppler ultrasound, but not low‐field magnetic resonance imaging, predicts relapse and radiographic disease progression in rheumatoid arthritis patients with low levels of disease activity

Cited by 206 publications

References 41 publications

The MRI Features in Patients with Rheumatoid Arthritis Treated with Tocilizumab, in Clinical Remission or Low Disease Activity State

The MRI Features in Patients with Rheumatoid Arthritis Treated with Tocilizumab, in Clinical Remission or Low Disease Activity State

Evaluation of Serum Interleukin‐6 Level as a Surrogate Marker of Synovial Inflammation and as a Factor of Structural Progression in Early Rheumatoid Arthritis: Results From a French National Multicenter Cohort

Diagnostic value of high-frequency ultrasound and magnetic resonance imaging in early rheumatoid arthritis

Contact Info

Product

Resources

About