Power of Words: Influence of Preexercise Information on Hypoalgesia after Exercise—Randomized Controlled Trial

Vægter, Henrik Bjarke; Thinggaard, Peter; Madsen, Casper Høj; Hasenbring, Monika; Thorlund, Jonas Bloch

doi:10.1249/mss.0000000000002396

Cited by 29 publications

(15 citation statements)

References 38 publications

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“…However, similar results have already been reported for studies that attempted to influence outcomes using other paradigms to quantify endogenous pain modulation by using suggestion. For example, a similar conclusion was reported by Vaegter et al (2020) which attempted to influence exercise-induced hypoalgesia (EIH) using suggestion [37]. In that study, EIH was defined as an increased pain threshold and pain tolerance induced by performing a single exercise routine.…”

Section: Discussionmentioning

confidence: 55%

Psychological mechanisms of offset analgesia: The effect of expectancy manipulation

Szikszay

Adamczyk

Panskus

et al. 2022

Preprint

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A frequently used paradigm to quantify endogenous pain modulation is offset analgesia, which is defined as a disproportionate large reduction in pain following a small decrease in a heat stimulus. The aim of this study was to determine whether suggestion influences the magnitude of offset analgesia in healthy participants. A total of 102 participants were randomized into three groups (hypoalgesic group, hyperalgesic group, control group). All participants received four heat stimuli (two constant trials and two offset trials) to the ventral, non-dominant forearm while they were asked to rate their perceived pain using a computerized visual analogue scale. In addition, electrodermal activity was measured during each heat stimulus. Participants in both intervention groups were given a visual and verbal suggestion about the expected pain response in an hypoalgesic and hyperalgesic manner. The control group received no suggestion. In all groups, significant offset analgesia was provoked, indicated by reduced pain ratings (p < 0.001) and enhanced electrodermal activity level (p < 0.01). A significant group difference in the magnitude of offset analgesia was found between the three groups (F[2,94] = 4.81, p < 0.05). Participants in the hyperalgesic group perceived significantly more pain than the hypoalgesic group (p = 0.031) and the control group (p < 0.05). However, the electrodermal activity data did not replicate this trend (p > 0.05). The results of this study indicate that suggestion can be effective to reduce but not increase endogenous pain modulation quantified by offset analgesia in healthy participants.

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Section: Discussionmentioning

confidence: 55%

Psychological mechanisms of offset analgesia: The effect of expectancy manipulation

Szikszay

Adamczyk

Panskus

et al. 2022

Preprint

View full text Add to dashboard Cite

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Section: Expectancy Mechanismmentioning

confidence: 66%

Psychological mechanisms of offset analgesia: The effect of expectancy manipulation

et al. 2023

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A frequently used paradigm to quantify endogenous pain modulation is offset analgesia, which is defined as a disproportionate large reduction in pain following a small decrease in a heat stimulus. The aim of this study was to determine whether suggestion influences the magnitude of offset analgesia in healthy participants. A total of 97 participants were randomized into three groups (hypoalgesic group, hyperalgesic group, control group). All participants received four heat stimuli (two constant trials and two offset trials) to the ventral, non-dominant forearm while they were asked to rate their perceived pain using a computerized visual analogue scale. In addition, electrodermal activity was measured during each heat stimulus. Participants in both intervention groups were given a visual and verbal suggestion about the expected pain response in an hypoalgesic and hyperalgesic manner. The control group received no suggestion. In all groups, significant offset analgesia was provoked, indicated by reduced pain ratings (p < 0.001) and enhanced electrodermal activity level (p < 0.01). A significant group difference in the magnitude of offset analgesia was found between the three groups (F[2,94] = 4.81, p < 0.05). Participants in the hyperalgesic group perceived significantly more pain than the hypoalgesic group (p = 0.031) and the control group (p < 0.05). However, the electrodermal activity data did not replicate this trend (p > 0.05). The results of this study indicate that suggestion can be effective to reduce but not increase endogenous pain modulation quantified by offset analgesia in healthy participants.

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“…61 Participants will receive neutral language instruction and complete familiarisation for one trial at each site following the procedures described above. 62 To test endogenous analgesia (descending pain inhibition) in response to exercise, pressure pain thresholds will be reassessed following a 3 min isometric wall squat with feet at shoulder width and knee joint angle of 100 degrees using an established protocol. 59 63 LBP intensity (visual analogue scale) will be evaluated immediately before and after the wall squat to determine a change in endogenous hypoalgesia.…”

Section: Social Supportmentioning

confidence: 99%

“…64 Following pressure pain thresholds, participants will complete a two-item questionnaire to determine expectations of the wall squat on changes in pressure pain thresholds and LBP intensity. 62 Adverse events Participants will be instructed to inform the research team immediately should any adverse events occur. Moreover, participants allocated to exercise training will be asked about adverse events during a fortnightly video consultation (Zoom Video Communications, California, USA) with a study team member.…”

Section: Social Supportmentioning

confidence: 99%

Assessing safety and treatment efficacy of running on intervertebral discs (ASTEROID) in adults with chronic low back pain: protocol for a randomised controlled trial

Tagliaferri

Belavý

Bowe

et al. 2023

BMJ Open Sport Exerc Med

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Poor intervertebral disc (IVD) health is associated with low back pain (LBP). This 12-week parallel randomised controlled trial will evaluate the efficacy of a progressive interval running programme on IVD health and other clinical outcomes in adults with chronic LBP. Participants will be randomised to either a digitally delivered progressive interval running programme or waitlist control. Participants randomised to the running programme will receive three individually tailored 30 min community-based sessions per week over 12 weeks. The waitlist control will undergo no formal intervention. All participants will be assessed at baseline, 6 and 12 weeks. Primary outcomes are IVD health (lumbar IVD T2 via MRI), average LBP intensity over the prior week (100-point visual analogue scale) and disability (Oswestry Disability Index). Secondary outcomes include a range of clinical measures. All outcomes will be analysed using linear mixed models. This study has received ethical approval from the Deakin University Human Research Ethics Committee (ID: 2022-162). All participants will provide informed written consent before participation. Regardless of the results, the findings of this study will be disseminated, and anonymised data will be shared via an online repository. This will be the first study to evaluate whether a progressive interval running programme can improve IVD health in adults with chronic LBP. Identifying conservative options to improve IVD health in this susceptible population group has the potential to markedly reduce the burden of disease. This study was registered via the Australian New Zealand Clinical Trials Registry on 29 September 2022 (ACTRN12622001276741).

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Power of Words: Influence of Preexercise Information on Hypoalgesia after Exercise—Randomized Controlled Trial

Cited by 29 publications

References 38 publications

Psychological mechanisms of offset analgesia: The effect of expectancy manipulation

Psychological mechanisms of offset analgesia: The effect of expectancy manipulation

Psychological mechanisms of offset analgesia: The effect of expectancy manipulation

Assessing safety and treatment efficacy of running on intervertebral discs (ASTEROID) in adults with chronic low back pain: protocol for a randomised controlled trial

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