This paper presents the design and implementation of a miniaturized high-voltage power supply with power factor correction (PFC) for atmospheric-pressure plasma jet (APPJ) applications. The sinusoidal output frequency and voltage of the power supply can be controlled independently from 16 to 24 kHz and from 1 to 10 kVpeak, respectively. A helium APPJ load is used to assess the performance of the developed power supply. It is shown that the developed high-voltage power supply operates effectively, and the designed PFC converter improves the input current distortion of the power supply. Not only the power factor of the power supply is increased from 0.41 to 0.95, but it also provides a low-ripple DC voltage, which reduces the high-voltage ripple of the output from 730 to 50 Vp-p. In this paper, the proposed design integrates the PFC converter into the high-voltage power supply so that the developed power supply has better electrical characteristics and the overall power supply can be significantly miniaturized.