[PP.10.13] Arterial Stiffness and Endothelial Function in Patients With Resistant Hypertension After Renal Denervation.

Shchelkova, G.; Zairova, A.; Данилов, Н. М.; Rogoza, A.; Чазова, И Е

doi:10.1097/01.hjh.0000491817.72712.2b

Cited by 5 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the recent hype, only very few studies have looked at the relation between RDN and arterial dysfunction, mainly yielding conflicting or nonconclusive results 28–31 . Moreover, it should be noticed that these studies are dragged down by several issues including the focus on systemic vasculature rather than on coronary microcirculation, the use of outdated technologies and small sample sizes; in addition, the enrollment of all-comers (not only patients with established hy-CMD) and the lack of invasive assessment of microvascular function are major limitations that should be kept in consideration.…”

Section: Introductionmentioning

confidence: 99%

Impact of renal denervation on patients with coronary microvascular dysfunction: study rationale and design

Migliaro,

Petrolini,

Mariani

et al. 2024

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

Aims Long-standing hypertension may cause an impairment in microvascular coronary circulation, which is involved in many different cardiac conditions. Renal sympathetic denervation (RDN) has been successfully proven as a valuable therapeutic choice for patients with resistant hypertension; moreover, the procedure looks promising in other settings, such as heart failure and atrial fibrillation, given its ability to downregulate the sympathetic nervous system, which is a recognized driver in these conditions as well as in microvascular dysfunction progression. The aim of this study is to explore the effect of RDN on coronary physiology in patients with ascertained coronary microvascular dysfunction and resistant hypertension. Methods This is a multicenter, prospective, nonrandomized, open-label, interventional study. Consecutive patients with resistant hypertension, nonobstructive coronary artery disease (NOCAD) and documented microvascular dysfunction will be enrolled. Patients will undergo RDN by Spyral Symplicity 3 (Medtronic Inc, Minneapolis, Minnesota, USA) and reassessment of coronary microvascular function 6 months after the procedure. Primary endpoint will be the difference in the index of microcirculatory resistance. Conclusion The IMPRESSION study seeks to evaluate if there is any pleiotropic effect of the RDN procedure that results in modulation of microvascular function; if observed, this would be the first evidence showing RDN as a valuable therapy to revert hypertension-related microvascular dysfunction.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of renal denervation on patients with coronary microvascular dysfunction: study rationale and design

Migliaro,

Petrolini,

Mariani

et al. 2024

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

show abstract

The role of intervention methods of treatment of patients with resistant hypertension in contemporary cardiology

Agaeva¹,

Данилов²,

Shelkova³

et al. 2018

Kardio. vestn.

View full text Add to dashboard Cite

Артериальная гипертония (АГ) является одним из самых распространенных хронических заболеваний. В настоящее время для лечения больных АГ существует большой арсенал современных гипотензивных препаратов, которые успешно применяются в клинической практике. Однако, несмотря на большие успехи медикаментозного лечения, у 10-20% пациентов с АГ не удается достичь целевого уровня артериального давления (АД) даже при применении всех возможных медикаментозных подходов, изменении образа жизни и высокой приверженности к лечению [1-3]. Этот вариант АГ называется истинной рефрактерной артериальной гипертонией (РАГ) и представляет собой актуальную проблему кардиологии. Наличие РАГ во много раз увеличивает риск развития сердечно-сосудистых осложнений. Лечение данной группы больных является не только сложной, но порой и неразрешимой задачей для клинициста. Такая ситуация привела к поиску нефармакологических интервенционных подходов к лечению больных АГ. В настоящее время при РАГ возможно применение интервенционных методов лечения, обеспечивающих снижение АД [2, 3]. Наиболее

show abstract

Renal denervation may attenuate the severity of MRI-signs of vascular wall damage in diabetic patients with resistant hypertension due to the anti-inflammatory effect

et al. 2020

View full text Add to dashboard Cite

[PP.10.13] Arterial Stiffness and Endothelial Function in Patients With Resistant Hypertension After Renal Denervation.

Cited by 5 publications

References 0 publications

Impact of renal denervation on patients with coronary microvascular dysfunction: study rationale and design

Impact of renal denervation on patients with coronary microvascular dysfunction: study rationale and design

The role of intervention methods of treatment of patients with resistant hypertension in contemporary cardiology

Renal denervation may attenuate the severity of MRI-signs of vascular wall damage in diabetic patients with resistant hypertension due to the anti-inflammatory effect

Contact Info

Product

Resources

About