PP.12.01

Arita, Mikio; Miyai, Nobuyuki; Yamamoto, Masakuni; Kaneta, M; Utsumi, Miyoko; Uemastu, Y.; Shiba, Mitsuru

doi:10.1097/01.hjh.0000468059.50237.7b

Cited by 2 publications

(1 citation statement)

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“…CCV HF indicates vagal modulation of the heart which is affected by exposure to drugs, clinical procedure, or disease and is calculated using the following equation: CCV HF (%) = 100 × (HF power) 1/2 /(mean RR interval), and these values correlate linearly to vagal activities (Arita et al, 2015; Chan et al, 2021; Hayano et al, 1991; Kawasaki, 2005).…”

Section: Methodsmentioning

confidence: 99%

Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Alyahya

Charman

Okwose

et al. 2023

Clin Physio Funct Imaging

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ObjectivesHeart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM.MethodsTwenty‐eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m2) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m2) completed 5‐min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low‐frequency power (LF), high‐frequency power (HF) and LF/HF ratio) and RR interval were recorded.ResultsIndividuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms2, p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml‎/beat‎/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m2, p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m2cm−5, p = 0.03). HF power was significantly related to SV (r = −0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM.ConclusionsShort‐term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.

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Section: Methodsmentioning

confidence: 99%

Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Alyahya

Charman

Okwose

et al. 2023

Clin Physio Funct Imaging

View full text Add to dashboard Cite

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Lifestyle Intervention Improves Parasympathetic Activity in Hypertrophic Cardiomyopathy

Alyahya,

Charman,

Okwose

et al. 2024

American Journal of Lifestyle Medicine

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Background A limited number of studies have investigated the effects of lifestyle interventions in hypertrophic cardiomyopathy (HCM). This study evaluated the effect of a novel lifestyle intervention incorporating physical activity (PA) and dietary nitrate supplementation on heart rate variability (HRV) and haemodynamic measures in HCM. Methods Twenty-eight individuals with HCM were randomised into either the intervention or control group. Frequency-domain HRV measures including low frequency power (LF), high frequency power (HF) and LF/HF were recorded at rest using bioimpedance. Non-invasive haemodynamic variables were recorded at rest using bioreactance. Participants in the intervention group consumed 6 mmol of nitrate daily (concentrated beetroot juice) and were instructed to increase and maintain daily PA by ≥ 2000 steps/day above baseline for 16 weeks. Control group participants retained their usual lifestyle and monitored daily step counts. Results There was a significant increase in post-intervention HF power (7.54 ± 2.14 vs 8.78 ± 1.60 ms2, P < .01) and LF power (6.89 ± 2.33 vs 8.17 ± 1.55, P < .01) in the intervention but not in the control group. Resting mean arterial blood pressure (MABP) in the intervention group significantly reduced at follow-up (108 ± 6 vs 102 ± 7 mmHg, P < .01). Conclusions A novel lifestyle intervention including PA and dietary nitrate supplementation enhanced parasympathetic activity and resting MABP in HCM.

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PP.12.01

Cited by 2 publications

References 0 publications

Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Lifestyle Intervention Improves Parasympathetic Activity in Hypertrophic Cardiomyopathy

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