PP-133 High prevalence of hepatitis C infection among high risk groups in Kohgiloyeh and Boyerahmad Province, Southwest of Iran

Sarkari, Bahador; Eilami, Owrang; Khosravani, Abdolmajid; Akbartabartori, M.; Tabatabaee, M.

doi:10.1016/s1201-9712(11)60285-3

Cited by 10 publications

(12 citation statements)

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“…Furthermore, positivity for anti-HCV was as high as 33% in studies conducted on Iranian patients with thalassemia major before 2000; however, this ratio was reported to have decreased to 15% -19% in recent years (6). In other studies on Iranian patients, anti-HCV was described in range of 6% -8% in patients with thalassemia (17,18). Moreover, in the studies carried out in Thailand (8) and Jordan (19), anti-HCV frequencies were 20% and 40% respectively in patients with thalassemia.…”

Section: Discussionmentioning

confidence: 95%

Characteristics of Seropositive Hepatitis B and C Thalassemia Major Patients in South-East of Iran

Bazi¹,

Miri‐Moghaddam²,

Rostami³

et al. 2016

Biotech Health Sci

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Background: Hepatitis is a serious blood born infection in patients with β-thalassemia major (β-TM). There was no previous report on hepatitis prevalence in patients with β-TM in Zabol, Iran. Objectives: The current study aimed to evaluate characteristics of hepatitis in patients with β-TM visiting Imam Khomeini Hospital of Zabol, in Sistan and Baluchistan province of Iran. Patients and Methods: There were 90 patients with β-TM. General demographic and laboratory results were obtained by interviews and reviewing clinical and laboratory histories. Data for anti-HCV, HBs antigen and anti-HBs were extracted from latest archived records, and analyzed using SPSS ver. 19. Results: Males and females comprised 51% and 49% of the patients, respectively. Mean age of the patients was 14.8±7.4 years old. Anti-HCV and HBs antigen were detected in 10% and 3.3% of the patients, respectively. Significant difference was found between the mean age of anti-HCV positive (20.1 ± 3.6, 95% CI: 17.3-22.9) and negative (14.2 ± 7.5, 95% CI: 12.5-15.9) patients (P = 0.02). Mean ferritin value was measured 4702 ± 2743 ng/mL. A significant correlation was observed between serum ferritin level and age (r = 0.3, P = 0.01). Hepatic enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) had mean levels of 51.8 ± 32.8 IU/L and 58.8 ± 59 IU/L, respectively. No significant association was identified between hepatitis status and either ferritin or hepatic enzymes levels. Conclusions: Results demonstrated the relatively high prevalence of HCV infection in the patients. Applying sensitive methods to screen blood units is recommended to minimize the risk of transfusion associated hepatitis.

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Section: Discussionmentioning

confidence: 95%

Characteristics of Seropositive Hepatitis B and C Thalassemia Major Patients in South-East of Iran

Bazi¹,

Miri‐Moghaddam²,

Rostami³

et al. 2016

Biotech Health Sci

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“…Some Iranian studies in different cities have reported various rate of HCV infection among IVDUs. For instance among IVDUs, 64.8% in Bandar Abbas, 34.5% in Tehran (14) and 42.4% in Kohgiloyeh and Boyerahmad (15) had HCVAb. Two meta-analysis from Iran have reported that the pooled HCV prevalence among IVDUs was 51% (34% -69%) and 45% (37% -54%) during 1996 -2012 and 2001 -2012, respectively (16,17).…”

Section: Discussionmentioning

confidence: 95%

Prevalence and Risk Factors for Occult Hepatitis B and HIV Infections Among HCV Infected Intravenous Drug Users, Tehran, Iran

Abadi

Kandelouei

Eslami

et al. 2018

Arch Clin Infect Dis

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Background: Exposure to hepatitis B virus (HBV) or human immunodeficiency virus (HIV) infection is common among hepatitis C virus (HCV)-infected Intra venous drug users (IVDUs); however there exist only a few data about frequency and risk factors of HCV, occult HBV infection (OBI) and HIV among IVDUs. Objectives: This study aimed to investigate the prevalence and associated risk factors for OBI and HIV infections among Iranian HCV infected IVDUs. Methods: Serum samples were screened for the presence of hepatitis C virus antibody (HCVAb), hepatitis B core antibody (HBcAb), hepatitis B surface antigen (HBsAg), and human immunodeficiency virus antibody/antigen (HIVAb/Ag) using enzyme linked immunosorbent assay (ELISA). For detection of OBI, presence of HBV DNA among HBcAb positive/HBsAg negative subjects was determined using nested polymerase chain reaction (PCR). Results: Among all subjects, 94 cases (53.5%) were positive for HCVAb from which 7% and 23.4% were positive for HCV/OBI and HCV/HIV co-infections, respectively. A significant association existed between HCVAb with type of drug, sharing syringes and needles and a history of imprisonment. In the case of HCV/OBI co-infections, the only significant correlation was between sharing a syringe and occult hepatitis B infection. Also no significant association existed between risk factors and HCV/HIV co-infections. Conclusions: the present data documented an alarming prevalence of HCV and HIV as well as co-infections among IVDUs, which emphasizes the requirement for expansion of public health interventions for this at-risk population. Despite previously high prevalence reported for HCV/HBV/HIV triple infections among IVDUs, low prevalence of triple HCV/OBI/HIV infections was obtained. The reason for this difference may be related to the effect of HCV on HBV expression in case of OBI which had been suggested previously.

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“…Sexual and maternal-infant HCV transmission can occur but it is rare [54] . Generally, the population at risk for HCV infections who are exposed to infected blood, hemodialysis, IDU, prisoners, tattooing, and during medical and dental care [55] . The most high prevalence rate of HCV occurs in African and Asian countries (5.3% in Africa and 2.15%-3.9% in Asia) [56,57] .…”

Section: Other Environmental and Genetic Risk Factors Of Hccmentioning

confidence: 99%

Hepatocellular carcinoma in Asia: Prevention strategy and planning

Ashtari¹,

Pourhoseingholi²,

Sharifian³

et al. 2015

WJH

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PP-133 High prevalence of hepatitis C infection among high risk groups in Kohgiloyeh and Boyerahmad Province, Southwest of Iran

Cited by 10 publications

References 0 publications

Characteristics of Seropositive Hepatitis B and C Thalassemia Major Patients in South-East of Iran

Characteristics of Seropositive Hepatitis B and C Thalassemia Major Patients in South-East of Iran

Prevalence and Risk Factors for Occult Hepatitis B and HIV Infections Among HCV Infected Intravenous Drug Users, Tehran, Iran

Hepatocellular carcinoma in Asia: Prevention strategy and planning

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