PPAR<i>α</i>Activation by Culinary Herbs and Spices

Mueller, Monika; Beck, Verena; Jungbauer, Alois

doi:10.1055/s-0030-1250435

Cited by 45 publications

(26 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PPAR agonists such as fibrates could improve the metabolic disorders including high TG level, high glucose level, insulin resistance, and atherosclerosis . Therefore saffron through PPARα activation can improve the lipid profile …”

Section: Effects On Dyslipidaemiamentioning

confidence: 99%

Saffron: a promising natural medicine in the treatment of metabolic syndrome

Razavi

Hosseinzadeh

2017

J. Sci. Food Agric.

100

View full text Add to dashboard Cite

Metabolic syndrome is a disorder which encompasses obesity, high blood glucose, high cholesterol levels and high blood pressure. Moreover, metabolic syndrome is considered as the most important risk factor for cardiovascular disease (CVD). CVD is the leading cause of mortality in the world for both men and women. Several chemical drugs are available to treat metabolic risk factors, but because of the safety, efficacy, cultural acceptability and lesser side effects, nowadays herbal therapy has a critical role in the treatment of these CVD risk factors. Crocus sativus L. (saffron) is a perennial herb that belongs to the Iridaceae family. Saffron is an extensively used food additive for its colour and taste and has been widely used in traditional as well as modern medicine to treat several illnesses including cardiovascular diseases. Most of the unique properties of this plant are attributed to the presence of three major components, including crocin, safranal and crocetin. It has been proved that saffron has an important role in the management of metabolic syndrome because of its marvelous activities including anti-diabetic, anti-obesity, hypotensive and hypolipidaemic properties. In this review article, we discuss the beneficial properties of saffron and its active components to treat different components of metabolic syndrome and most relevant animal and human studies regarding the use of this plant in cardiovascular disease, with focus on the metabolic risk factors. This review also suggests that after randomised clinical trials, saffron may be implicated as a preventive or therapeutic agent against metabolic syndrome. © 2016 Society of Chemical Industry.

show abstract

Section: Effects On Dyslipidaemiamentioning

confidence: 99%

Saffron: a promising natural medicine in the treatment of metabolic syndrome

Razavi

Hosseinzadeh

2017

J. Sci. Food Agric.

100

View full text Add to dashboard Cite

show abstract

“…Spices are effective and powerful preventative agents because they modify risk factors associated with CVD, including raised cholesterol and triglyceride levels, high blood pressure, sticky platelets, and chronic systemic inflammation. Caraway, chili pepper, nutmeg, licorice, black pepper, white pepper, paprika, coriander, and saffron all exhibit low to moderate PPARα transactivation, which helps to improve the lipid profile and reduce the risk of CVD (Mueller et al, 2011). In addition, curcumin was shown to inhibit CRP-induced PAI-1 mRNA expression in human endothelial cells, thereby indicating its cardioprotective properties (Chen et al, 2008).…”

Section: Dietary Agents Inflammation and Chronic Diseasesmentioning

confidence: 99%

Age-associated chronic diseases require age-old medicine: Role of chronic inflammation

Prasad

Sung

Aggarwal³

2012

Preventive Medicine

250

163

View full text Add to dashboard Cite

Most chronic diseases - such as cancer, cardiovascular disease (CVD), Alzheimer disease, Parkinson disease, arthritis, diabetes and obesity - are becoming leading causes of disability and death all over the world. Some of the most common causes of these age-associated chronic diseases are lack of physical activity, poor nutrition, tobacco use, and excessive alcohol consumption. All the risk factors linked to these chronic diseases have been shown to up-regulate inflammation. Therefore, downregulation of inflammation-associated risk factors could prevent or delay these age-associated diseases. Although modern science has developed several drugs for treating chronic diseases, most of these drugs are enormously expensive and are associated with serious side effects and morbidity. In this review, we present evidence on how chronic inflammation leads to age-associated chronic disease. Furthermore, we discuss diet and lifestyle as solutions for age-associated chronic disease.

show abstract

“…Recent research has shown that capsaicin activates PPARα in vitro with an EC 50 of 50 μM (Mueller et al 2011). In addition, dietary capsaicin enhances fatty acid oxidation in adipose tissue through PPARα activation (Kang et al 2010).…”

Section: Peroxisome Proliferator-activated Receptorsmentioning

confidence: 99%

The Potential Antitumor Effects of Capsaicin

Díaz‐Laviada

Rodríguez-Henche

2014

Capsaicin as a Therapeutic Molecule

View full text Add to dashboard Cite

Capsaicin, one of the major pungent ingredients found in red peppers, has been recently demonstrated to induce apoptosis in many types of malignant cell lines including colon adenocarcinoma, pancreatic cancer, hepatocellular carcinoma, prostate cancer, breast cancer, and many others. The mechanism whereby capsaicin induces apoptosis in cancer cells is not completely elucidated but involves intracellular calcium increase, reactive oxygen species generation, disruption of mitochondrial membrane transition potential, and activation of transcription factors such as NFκB and STATS. Recently, a role for the AMP-dependent kinase (AMPK) and autophagy pathways in capsaicin-triggered cell death has been proposed. In addition, capsaicin shows antitumor activity in vivo by reducing the growth of many tumors induced in mice. In this chapter, we report the last advances performed in the antitumor activity of capsaicin and review the main signaling pathways involved. CapsaicinCapsaicin (8-methyl-N-vanillyl-6-noneamide) is the major constituent of the peppers belonging to the genus Capsicum and responsible for their spicy flavor and burning sensation, also known as pungency. Besides capsaicin, a family of related compounds are present in Capsicum sp. plants, all referred as capsaicinoids. These compounds are capsaicin, dihydrocapsaicin, nordihydrocapsaicin, and homocapsaicin. Capsaicin

show abstract

PPARαActivation by Culinary Herbs and Spices

Cited by 45 publications

References 19 publications

Saffron: a promising natural medicine in the treatment of metabolic syndrome

Saffron: a promising natural medicine in the treatment of metabolic syndrome

Age-associated chronic diseases require age-old medicine: Role of chronic inflammation

The Potential Antitumor Effects of Capsaicin

Contact Info

Product

Resources

About