PPARα Regulates the Proliferation of Human Glioma Cells through miR-214 and E2F2

Gao, Yong; Han, Dan; Sun, Laisheng; Huang, Qihua; Gai, Guangchao; Wu, Zicheng; Wang, Meng; Chen, Xincheng

doi:10.1155/2018/3842753

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…Previous study reported that miR-199a-5p significantly regulated cell proliferation, migration, and invasion. 18,22,23 In glioma, Zhang et al reported that miR-199a inhibits tumor growth and attenuates chemoresistance by targeting K-RAS via ATK and ERK signaling. 24 Our previous study also found that miR199a-5p suppresses glioma cell proliferation, migration, and invasion by inhibiting MAGT1.…”

Section: Discussionmentioning

confidence: 99%

CELSR1 Acts as an Oncogene Regulated by miR-199a-5p in Glioma

Wang

Zhang

et al. 2020

CMAR

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This study aimed to elucidate the biological function and upstream regulatory mechanism of CELSR1 in glioma. Materials and Methods: We evaluated the expression of CELSR1 in glioma by TCGA_GEPIA tool, RT-qPCR, and Western blot assays. CCK-8, wound healing, and transwell invasion assays were, respectively, performed to detect the effect of CELSR1 on cell proliferation, migration, and invasion. The upstream regulatory miRNAs of CELSR1 were predicted by TargetScan and validated by luciferase activity reporter assay. Results: CELSR1 is overexpressed in glioma (P<0.05). CELSR1 promoted glioma cell proliferation, migration and invasion (P<0.01). CELSR1 was a direct target of miR-199a-5p. miR199a-5p mimics significantly inhibited CELSR1 mRNA and protein expression (P<0.01). miR199a-5p mimics reversed the effects of CELSR1 on glioma cell behaviors (P<0.01). Conclusion: CELSR1 acts as an oncogene promoting glioma cell proliferation, migration, and invasion, which is regulated by miR199a-5p.

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Section: Discussionmentioning

confidence: 99%

CELSR1 Acts as an Oncogene Regulated by miR-199a-5p in Glioma

Wang

Zhang

et al. 2020

CMAR

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“…GSE103229 (https://www.ncbi.nlm.nih.gov/geo/query/acc .cgi?acc=GSE103229) contains five nontumor brain tissues and five glioma tissues. The GSE4290 and CGGA database information refers to our previous description [33,34]. TCGA (https://www.cancer.gov/about-nci/organization/ccg/research/ structural-genomics/tcga) contains 555 glioma specimens, including 210 in the World Health Organization (WHO) II, 233 in the WHO III, and 112 in the WHO IV.…”

Section: Methodsmentioning

confidence: 99%

PART1 and hsa‐miR‐429‐Mediated SHCBP1 Expression Is an Independent Predictor of Poor Prognosis in Glioma Patients

Xuan¹,

Jin²,

Wang³

et al. 2020

BioMed Research International

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Gliomas are the most common primary brain tumors. Because of their high degree of malignancy, patient survival rates are unsatisfactory. Therefore, exploring glioma biomarkers will play a key role in early diagnosis, guiding treatment, and monitoring the prognosis of gliomas. We found two lncRNAs, six miRNAs, and nine mRNAs that were differentially expressed by analyzing genomic data of glioma patients. The diagnostic value of mRNA expression levels in gliomas was determined by receiver operating characteristic (ROC) curve analysis. Among the nine mRNAs, the area under the ROC curve values of only CEP55 and SHCBP1 were >0.7, specifically 0.834 and 0.816, respectively. Additionally, CEP55 and SHCBP1 were highly expressed in glioma specimens and showed increased expression according to the glioma grade, and outcomes of high expression patients were poor. CEP55 was enriched in the cell cycle, DNA replication, mismatch repair, and P53 signaling pathway. SHCBP1 was enriched in the cell cycle, DNA replication, ECM receptor interaction, and P53 signaling pathway. Age, grade, IDH status, chromosome 19/20 cogain, and SHCBP1 were independent factors for prognosis. Our findings suggest the PART1-hsa-miR-429-SHCBP1 regulatory network plays an important role in gliomas.

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“…The CGGA contains 301 glioma samples (including 84 astrocytoma, 89 oligodendroglioma and 128 glioblastoma samples). The grouping of low-grade glioma (LGG), AG and GBM was performed as previously described (14). The GSE16011 dataset () contains 276 glioma samples (including samples from 8 patients with epilepsy and 24 astrocytoma, 85 oligodendroglioma and 159 glioblastoma samples) and 8 control samples, totaling 284 specimens (15).…”

Section: Methodsmentioning

confidence: 99%

Ubiquitin ligase RNF5 serves an important role in the development of human glioma

et al. 2019

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The ubiquitin ligase ring finger protein 5 (RNF5) has previously been associated with the development of breast cancer. Patients with breast cancer and high RNF5 expression have been demonstrated to have a shorter survival time compared with patients with low RNF5 expression. However, the role of RNF5 in human glioma has not been determined. The present study analyzed the role of RNF5 in gliomas using bioinformatics analysis. The results revealed that RNF5 was differentially expressed in non-cancerous brain tissues and different grades of glioma. Furthermore, a high RNF5 expression in patients with glioma was associated with an improved prognosis compared with patients with low expression. Gene Set Enrichment Analysis revealed that RNF5 was particularly associated with ‘Wnt signaling pathway’, ‘apoptosis’, ‘focal adhesion’ and ‘cytokine-cytokine receptor interaction’ in patients with glioma. Additionally, 4 potential ubiquitination substrates for RNF5 were predicted, including sorting nexin 10, proprotein convertase subtilisin/kexin type 1, leucine rich glioma inactivated 1 and solute carrier family 39 member 12. These findings provided the basis for further investigation on the role of RNF5 in tumors.

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PPARα Regulates the Proliferation of Human Glioma Cells through miR-214 and E2F2

Cited by 19 publications

References 25 publications

<p>CELSR1 Acts as an Oncogene Regulated by miR-199a-5p in Glioma</p>

<p>CELSR1 Acts as an Oncogene Regulated by miR-199a-5p in Glioma</p>

PART1 and hsa‐miR‐429‐Mediated SHCBP1 Expression Is an Independent Predictor of Poor Prognosis in Glioma Patients

Ubiquitin ligase RNF5 serves an important role in the development of human glioma

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