PPAR-γ agonist rosiglitazone reduces autophagy and promotes functional recovery in experimental traumaticspinal cord injury

Liu, Hongpeng; Zhang, Qin; Yang, Xiaohui; Wang, Liping

doi:10.1016/j.neulet.2017.02.075

Cited by 23 publications

(17 citation statements)

References 39 publications

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“…Yang, et al, 2010). As indicated in Table 1, compromised autophagy was also noted in livers, skeletal muscle and adipose tissues from diet- and dehydroepiandrosterone-induced insulin resistance (X. Li, et al, 2017; Qian, et al, 2018; X.…”

Section: Autophagy Regulation In Cardiorenal Metabolic Function (Shormentioning

confidence: 89%

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Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Zhang

Whaley‐Connell

Sowers

et al. 2018

Pharmacology & Therapeutics

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Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (ER) stress, apoptosis, mitochondrial damage, and inflammation. Accumulating evidence has recently suggested a pivotal role for proteotoxicity, the unfavorable effects of poor protein quality control, in the pathophysiology of metabolic dysregulation and related cardiovascular complications. The ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathways, two major although distinct cellular clearance machineries, govern protein quality control by degradation and clearance of long-lived or damaged proteins and organelles. Ample evidence has depicted an important role for protein quality control, particularly autophagy, in the maintenance of metabolic homeostasis. To this end, autophagy offers promising targets for novel strategies to prevent and treat cardiorenal metabolic diseases. Targeting autophagy using pharmacological or natural agents exhibits exciting new strategies for the growing problem of cardiorenal metabolic disorders.

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Section: Autophagy Regulation In Cardiorenal Metabolic Function (Shormentioning

confidence: 89%

“…Xu & Sweeney, 2015). Although autophagy may protect ß-cell function (Marsh, et al, 2007), excessive autophagy leads to apoptosis and insulin resistance in cardiomyocytes and ß-cells in stress conditions (Fujitani, Ueno, & Watada, 2010; S. Li, H. Li, et al, 2017).…”

Section: Autophagy Regulation In Cardiorenal Metabolic Function (Shormentioning

confidence: 99%

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Zhang

Whaley‐Connell

Sowers

et al. 2018

Pharmacology & Therapeutics

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“…Autophagy is an intracellular degradative process that recycles cytoplasm to maintain cellular survival and stability, 42 and evidence revealed that neuroprotective effects of autophagy existed in neurological injury, including spinal cord injury and brain injury. 43 , 44 , 45 , 46 A recently study revealed that a novel indentified circular RNA, circHECTD1, may play important roles in cerebral ischemic stroke by inhibiting astrocyte activation via autophagy. 47 Here, our experiment showed that autophagy was induced both in spinal neurons and sciatic nerve tissue under injured conditions, and circRNA.2837-induced autophagy protected neurons from injury, indicating that autophagy was activated in sciatic nerve after injury and activation of neuronal autophagy might be a strategy for the treatment of SNI.…”

Section: Discussionmentioning

confidence: 99%

Silencing of circRNA.2837 Plays a Protective Role in Sciatic Nerve Injury by Sponging the miR-34 Family via Regulating Neuronal Autophagy

Zhou

Niu

Huang

et al. 2018

Molecular Therapy - Nucleic Acids

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Circular RNAs (circRNAs) represent a class of non-coding RNAs that are involved in transcriptional and posttranscriptional gene expression regulation and associated with different kinds of human diseases. However, the characterization and function of circular RNAs in peripheral nerve injuries remain elusive. Here, we established a rat sciatic nerve injury model and identified at least 4,942 distinct circular RNA candidates and a series of circular RNAs that were differentially expressed in injured nerve tissues compared with matched normal tissues. We characterized one frequently downregulated circular RNA, circRNA.2837, and further investigated its function in sciatic nerve injury. We found that circRNA.2837 regulated autophagy in neurons in vitro and in vivo, and downregulation of circRNA.2837 alleviated sciatic nerve injury via inducing autophagy in vivo. Mechanistically, knockdown of circRNA.2837 may protect neurons against neurological injury by acting as a sponge for members of miR-34 family. Our findings suggested that differentially expressed circular RNAs were involved in the pathogenesis of sciatic nerve injury, and circular RNAs exerted regulatory functions in sciatic nerve injury and might be used as potential targets in sciatic nerve injury therapy.

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“…Furthermore, miR-449a is involved in the regulation of autophagy (37), which serves a role in SCI (38). Administration of rosiglitazone may decrease autophagy and promote recovery in experimental traumatic SCI (39). Therefore, miR-449 may be involved in traumatic SCI development.…”

Section: Discussionmentioning

confidence: 99%

MAP‑1B, PACS‑2 and AHCYL1 are regulated by miR‑34A/B/C and miR‑449 in neuroplasticity following traumatic spinal cord injury in rats: Preliminary explorative results from microarray data

et al. 2019

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Spinal cord injury (SCI) is a specific type of damage to the central nervous system causing temporary or permanent changes in its function. The present aimed to identify the genetic changes in neuroplasticity following SCI in rats. The GSE52763 microarray dataset, which included 15 samples [3 sham (1 week), 4 injury only (1 week), 4 injury only (3 weeks), 4 injury + treadmill (3 weeks)] was downloaded from the Gene Expression Omnibus database. An empirical Bayes linear regression model in limma package was used to identify the differentially expressed genes (DEGs) in injury vs. sham and treadmill vs. non-treadmill comparison groups. Subsequently, time series and enrichment analyses were performed using pheatmap and clusterProfile packages, respectively. Additionally, protein-protein interaction (PPI) and transcription factor (TF)-microRNA (miRNA)-target regulatory networks were constructed using Cytoscape software. In total, 159 and 105 DEGs were identified in injury vs. sham groups and treadmill vs. non-treadmill groups, respectively. There were 40 genes in cluster 1 that presented increased expression levels in the injury (1 week/3 weeks) groups compared with the sham group, and decreased expression levels in the injury + treadmill group compared with the injury only groups; conversely, 52 genes in cluster 2 exhibited decreased expression levels in the injury (1 week/3 weeks) groups compared with the sham group, and increased expression levels in the injury + treadmill group compared with the injury only groups. Enrichment analysis indicated that clusters 1 and 2 were associated with immune response and signal transduction, respectively. Furthermore, microtubule associated protein 1B, phosphofurin acidic cluster sorting protein 2 and adenosylhomocysteinase-like 1 exhibited the highest degrees in the regulatory network, and were regulated by miRNAs including miR-34A, miR-34B, miR-34C and miR-449. These miRNAs and their target genes may serve important roles in neuroplasticity following traumatic SCI in rats. Nevertheless, additional in-depth studies are required to confirm these data.

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PPAR-γ agonist rosiglitazone reduces autophagy and promotes functional recovery in experimental traumaticspinal cord injury

Cited by 23 publications

References 39 publications

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Silencing of circRNA.2837 Plays a Protective Role in Sciatic Nerve Injury by Sponging the miR-34 Family via Regulating Neuronal Autophagy

MAP‑1B, PACS‑2 and AHCYL1 are regulated by miR‑34A/B/C and miR‑449 in neuroplasticity following traumatic spinal cord injury in rats: Preliminary explorative results from microarray data

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