PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis

Abstract

ABSTRACT. We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferatoractivated receptor gamma (PPARg) gene are associated with susceptibility to Alzheimer's disease (AD). We conducted a metaanalysis of the associations between the PPARg Pro12Ala and His447His polymorphisms and AD in subjects. The meta-analysis was performed according to the apolipoprotein E (APOE) ɛ4 allele status. A total of eight studies were considered in our meta-analysis, comprising 2948 patients with AD and 3753 controls. Meta-analysis showed no association between AD and the PPARg Pro12Ala G allele in any of the study subjects [odds ratio (OR) = 1.013, 95% confidence interval (95%CI) = 0.906-1.132, P = 0.821] or in the European and Asian populations (OR = 0.997, 95%CI = 0.890-1.118, P = 0.965; OR = 1.409, 95%CI = 0.832-2.387, P = 0.202, respectively). We tested whether the APOE ɛ4 allele affects the association between the PPARg Pro12Ala polymorphism and AD. Meta-analysis showed no association between AD and the PPARg G allele in any of the study subjects with or without the APOE ɛ4 allele. Meta-analysis showed no association between AD and the PPARg His447His T allele in the European population (OR for T allele = 0.912, 95%CI = 0.732-1.136, P = 0.409). This meta-analysis has shown that there is a lack of association between the PPARg Pro12Ala and His447His polymorphisms and AD risk.

Knowledge-Based Neuroendocrine Immunomodulation (NIM) Molecular Network Construction and Its Application

“…Similarly, in the second study case, we found that the differentially expressed (such as VDR [ 60 ], SP1 [ 61 ], CREB1 [ 62 ], and RELB [ 63 ]) and the non-differentially expressed (such as ESR1 [ 64 ], PPARG [ 65 ], ESR2 [ 66 ], and PPARD [ 67 ]) genes are AD-related genes. Besides this, we also found that some of the hub nodes in the network are not included in the AD-related gene dataset, such as the differentially expressed genes RXRA , STAT3 , STAT1 , PSMD14 , and so forth, and the non-differentially expressed HNF4A , PGR , ESRRA , THRB , and so forth, which are worth paying more attention to in further study.…”

Alzheimer’s Disease Neuroprotection: Associated Receptors

“…In addition, emerging evidence suggests that PPARγ effectively regulates microglia activation under physiological and pathological conditions, facilitating Aβ microglial phagocytosis [53]. In addition, PPARγ polymorphisms have been studied in AD; however, the results are controversial and inconclusive [54].…”