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Eg, Kolokol'chikova; Li, Budkevich; Bobrovnikov, Alexandr Eduardovich; Ak, Badikova; Vp, Tumanov

doi:10.1023/a:1017503301550

Cited by 17 publications

(4 citation statements)

References 2 publications

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“…Morphological findings also confirmed the stimulatory effect of AF in burn wound healing [3]. However, regular use of living cultured AF for the treatment of burn wounds is difficult, requires special conditions for maintenance of fibroblast culture and preparation of these cells to transplantation.…”

supporting

confidence: 57%

The use of bioactive wound dressing, stimulating epithelial regeneration of IIIa-degree burn wounds

et al. 2008

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Clinical and morphological comparison of wound healing after transplantation of living cultured allofibroblast on days 1-2 after the injury, collagen-1-based dressing with PDGF-BB, and traditional dressing with levomecol ointment showed that bioactive dressing accelerated wound epithelialization (5-7 days vs. 20-22 days with gauze dressing); the incidence of suppurative complications decreased, no crust formed, and epithelialization was not associated with the formation of a hypertrophic cicatrix. Biological dressing based on living cultured allofibroblasts and collagen-1 with PDGF-BB exhibited equal stimulatory effects on burn wound healing.

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supporting

confidence: 57%

The use of bioactive wound dressing, stimulating epithelial regeneration of IIIa-degree burn wounds

et al. 2008

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“…Long-term preservation of allogeneic fibroblasts and their proliferation up to two months in the host without signs of immune rejection have also been reported (Sher et al 1983;Bell et al 1984;Eaglstein et al 1999;Hebda & Dohar 1999;Sandulache et al 2003;Griffiths et al 2004). However, porcine studies could not confirm allogeneic fibroblast survival beyond a 7-day time point (Price et al 2004), nor could some clinical studies when allogeneic fibroblasts were transplanted onto burn wounds (Kolokol'chikova et al 2001). Allogeneic keratinocytes provide effective pain relief and accelerate wound healing, but they do not survive longer than a few weeks when applied to the wound because they are rejected by the host (Strande et al 1997;Clark et al 2007).…”

Section: Dermo-epidermal (Composite) Skin Substitutesmentioning

confidence: 93%

A review of tissue-engineered skin bioconstructs available for skin reconstruction

Shevchenko

James

2009

J. R. Soc. Interface.

629

469

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Situations where normal autografts cannot be used to replace damaged skin often lead to a greater risk of mortality, prolonged hospital stay and increased expenditure for the National Health Service. There is a substantial need for tissue-engineered skin bioconstructs and research is active in this field. Significant progress has been made over the years in the development and clinical use of bioengineered components of the various skin layers. Off-the-shelf availability of such constructs, or production of sufficient quantities of biological materials to aid rapid wound closure, are often the only means to help patients with major skin loss. The aim of this review is to describe those materials already commercially available for clinical use as well as to give a short insight to those under development. It seeks to provide skin scientists/tissue engineers with the information required to not only develop in vitro models of skin, but to move closer to achieving the ultimate goal of an off-the-shelf, complete full-thickness skin replacement.

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“…Cell therapy of surface and deep burn wounds now became a part of combined treatment of patients with burns [1][2][3].…”

mentioning

confidence: 99%

First experience in the use of bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns

et al. 2005

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Female patient with extensive skin burn (I-II-IIIAB skin burn, total area 40%, area of IIIB degree 30%) was treated using transplantation of allogenic fibroblast-like bone marrow mesenchymal stem cells onto the surface of deep thermal burn. The study of wound healing dynamics after transplantation of allogenic fibroblast-like mesenchymal stem cells confirmed high tempo of wound regeneration in the presence of active neoangiogenesis. Due to this, autodermoplasty of burn wounds could be carried out with good results as early as on day 4 after transplantation of fibroblast-like mesenchymal stem cells; this led to more rapid healing of donor zones and accelerated rehabilitation of the patient.

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Untitled

Cited by 17 publications

References 2 publications

The use of bioactive wound dressing, stimulating epithelial regeneration of IIIa-degree burn wounds

The use of bioactive wound dressing, stimulating epithelial regeneration of IIIa-degree burn wounds

A review of tissue-engineered skin bioconstructs available for skin reconstruction

First experience in the use of bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns

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