In recent years, using clustering technology to process large-scale data streams is a research hotspot in the field of data mining. However, for the processing of large-scale data streams, most existing methods suffer from slow speed, insufficient memory, and lack of detection and response mechanisms for concept drift. In this paper, a Large-Scale Stream K-measn based on product-quantized codes (LS2K-means) is proposed. By first introducing product quantization code into the framework of incremental clustering methods, memory space consumption is reduced through the dimensionality reduction of data. Additionally, a new similarity measurement method is introduced, greatly improving the efficiency of distance calculation. A concept drift detection and response mechanism is constructed. By comparing the consistency of clustering results, concept drift can be quickly detected, and a backtracking mechanism is utilized to respond to concept drift promptly, effectively improving the algorithm’s performance. The effectiveness of the proposed method is validated through simulations on six real datasets. The method efficiently handles concept drift and outperforms DenStream and EmCStream in terms of execution efficiency.