PR domaincontaining protein 12 (<i>prdm12</i>) is a downstream target of the transcription factor <i>zic1</i> during cellular differentiation in the central nervous system

Rahman, Md. Mahfujur; Kim, In-Shik; Ahn, Dongchoon; Tae, Hyun‐Jin; Park, Byung-Yong

doi:10.1002/jdn.10048

Cited by 4 publications

(6 citation statements)

References 43 publications

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“…Altogether, the mutual relationship between Prdm12 and Kdm4a indicated that the modification of the H3K9 methylation levels on the neural crest gene promoters by these two proteins would determine a demarcation line between the pre-placodal ectoderm and the neural crest region [ 37 ]. Interestingly, a recent analysis, performed to screen for zic1 targets in the midbrain region of Xenopus , revealed that prdm12 was a downstream target of zic1 [ 21 ]. Zic1 is a highly conserved zinc finger transcription factor playing a critical role in the establishment of the nervous system; it is expressed on the lateral edge of the neural plate and in the dorsal neural tube [ 21 ].…”

Section: Established Prdm12 Functions: Neurogenesismentioning

confidence: 99%

“…Interestingly, a recent analysis, performed to screen for zic1 targets in the midbrain region of Xenopus , revealed that prdm12 was a downstream target of zic1 [ 21 ]. Zic1 is a highly conserved zinc finger transcription factor playing a critical role in the establishment of the nervous system; it is expressed on the lateral edge of the neural plate and in the dorsal neural tube [ 21 ]. Here, prdm12 was expressed in the caudal forebrain, midbrain and hindbrain.…”

Section: Established Prdm12 Functions: Neurogenesismentioning

confidence: 99%

“…Moreover, during embryonic development, zic1 and prdm12 were co-expressed in the same cell, with Zic1 controlling the expression of prdm12 mediated by Wnt signaling during brain cell differentiation. Additionally, gain- and loss-of-function experiments revealed that prdm12 was both necessary and sufficient to promote midbrain formation in the embryo [ 21 ].…”

Section: Established Prdm12 Functions: Neurogenesismentioning

confidence: 99%

“…Prdm16 is also a crucial player in brain development and homeostasis; specifically, it controls neural stem cell maintenance and proliferation, intermediate progenitor proliferation, neuronal cell migration and ependymal cell differentiation, at least in part, by regulating genes involved in reactive oxygen species levels and the epigenetic states of its bound enhancers [ 16 , 17 , 18 ]. Similarly, PRDM12 is proposed as a “master regulator” of the nervous system regulatory cascade as it is required for midbrain cell differentiation [ 11 , 19 , 20 , 21 ]. PRDM12 could be detected in the mouse brain from embryonic day E10.5 and was expressed in different diencephalon and hypothalamus regions during embryogenesis, whereas, in humans, its expression was reported only in the peripheral nervous system [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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PRDM12 in Health and Diseases

Rienzo

Zazzo

Casamassimi

et al. 2021

IJMS

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PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1) homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc finger proteins, controlling key processes in the development of cancer. PRDM12 is expressed in a spatio-temporal manner in neuronal systems where it exerts multiple functions. PRDM12 is essential for the neurogenesis initiation and activation of a cascade of downstream pro-neuronal transcription factors in the nociceptive lineage. PRDM12 inactivation, indeed, results in a complete absence of the nociceptive lineage, which is essential for pain perception. Additionally, PRDM12 contributes to the early establishment of anorexigenic neuron identity and the maintenance of high expression levels of pro-opiomelanocortin, which impacts on the program bodyweight homeostasis. PRDMs are commonly involved in cancer, where they act as oncogenes/tumor suppressors in a “Yin and Yang” manner. PRDM12 is not usually expressed in adult normal tissues but its expression is re-activated in several cancer types. However, little information is currently available on PRDM12 expression in cancers and its mechanism of action has not been thoroughly described. In this review, we summarize the recent findings regarding PRDM12 by focusing on four main biological processes: neurogenesis, pain perception, oncogenesis and cell metabolism. Moreover, we wish to highlight the importance of future studies focusing on the PRDM12 signaling pathway(s) and its role in cancer onset and progression.

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Section: Established Prdm12 Functions: Neurogenesismentioning

confidence: 99%

Section: Established Prdm12 Functions: Neurogenesismentioning

confidence: 99%

Section: Established Prdm12 Functions: Neurogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

PRDM12 in Health and Diseases

Rienzo

Zazzo

Casamassimi

et al. 2021

IJMS

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“…These phenotypic changes are reflected in the underlying gene regulatory networks. The majority of the upregulated genes in the coccygeal tissue samples are involved in differentiation and development of the nervous system (e.g., NEUROD6, PRDM12, COCH, APBA2) (Uittenbogaard, Baxter, and Chiaramello 2010;Rahman et al 2020), or are genes that are expressed during skeletal muscle development (e.g., ACTN2) (Mills et al 2001). Apart from these, the rest of the upregulated genes within coccygeal tissues are directly involved in chondrocyte/osteocyte differentiation (e.g., RUNX2, COL9A1, SOX8) (Fig.…”

Section: Disparity In Gene Expression Profiles Of the Coccyx And Hypochordmentioning

confidence: 99%

Molecular Basis of Urostyle Development: Genes and Gene Regulation Underlying an Evolutionary Novelty

Senevirathne

Shubin

2021

Preprint

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Evolutionary novelties entail the origin of morphologies that enable new functions. These features can arise through changes to gene function and regulation. One important novelty is the fused rod at the end of the vertebral column in anurans, the urostyle. This feature is composed of a coccyx and an ossifying hypochord, and both structures ossify during metamorphosis. We used Laser Capture Micro-dissection of these identified tissues and subjected them to RNA-seq and ATAC-seq analyses at three developmental stages in tadpoles of Xenopus tropicalis. These experiments reveal that the coccyx and hypochord have two different molecular signatures. ATAC-seq data reveals potential regulatory regions that are observed in proximity to candidate genes identified from RNA-seq. Neuronal (TUBB3) and muscle markers (MYH3) are upregulated in coccygeal tissues, whereas T-box genes (TBXT, TBXT.2), corticosteroid stress hormones (CRCH.1), and matrix metallopeptidases (MMP1, MMP8, MMP13) are upregulated in the hypochord. Even though an ossifying hypochord is only present in anurans, this ossification between the vertebral column and the notochord appears to resemble a congenital vertebral anomaly seen prenatally in humans, caused by an ectopic expression of the TBXT/TBXT.2 gene. This work opens the way to functional studies that help us better elucidate anuran bauplan evolution.

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Molecular basis of urostyle development in frogs: genes and gene regulation underlying an evolutionary novelty

Senevirathne,

Shubin

2024

Open Biol.

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Evolutionary novelties entail the origin of morphologies that enable new functions. These features can arise through changes to gene function and regulation. One key novelty is the fused rod at the end of the vertebral column in anurans, the urostyle. This feature is composed of a coccyx and a hypochord, both of which ossify during metamorphosis. To elucidate the genetic basis of these features, we used laser capture microdissection of these tissues and did RNA-seq and ATAC-seq at three developmental stages in tadpoles of Xenopus tropicalis . RNA-seq reveals that the coccyx and hypochord have two different molecular signatures. Neuronal ( TUBB3 ) and muscle markers ( MYH3 ) are upregulated in coccygeal tissues, whereas T-box genes ( TBXT , TBXT.2 ), corticosteroid stress hormones ( CRCH.1 ) and matrix metallopeptidases ( MMP1 , MMP8 and MMP13 ) are upregulated in the hypochord. ATAC-seq reveals potential regulatory regions that are observed in proximity to candidate genes that regulate ossification identified from RNA-seq. Even though an ossifying hypochord is only present in anurans, this ossification between the vertebral column and the notochord resembles a congenital vertebral anomaly seen prenatally in humans caused by an ectopic expression of the TBXT / TBXT.2 gene. This work opens the way to functional studies that can elucidate anuran bauplan evolution.

show abstract

PR domaincontaining protein 12 (prdm12) is a downstream target of the transcription factor zic1 during cellular differentiation in the central nervous system

Cited by 4 publications

References 43 publications

PRDM12 in Health and Diseases

PRDM12 in Health and Diseases

Molecular Basis of Urostyle Development: Genes and Gene Regulation Underlying an Evolutionary Novelty

Molecular basis of urostyle development in frogs: genes and gene regulation underlying an evolutionary novelty

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