Although many studies have been conducted on the human factors and ergonomics (HFE) of touchscreens, no comprehensive review has summarized the findings of these studies. Based on a schema (three dimensions of understanding critical for successful display selection) presented by Wickens et al. (2004), we identified three dimensions of analysis for touchscreen implementations: touchscreen technology, setting and environment of implementation, and user population. We conducted a systematic review based on the PRISMA protocol (Moher et al., 2009), searching five article databases for relevant quantitative literature on touchscreens. We found that all three dimensions of analysis have a significant effect on the HFE of touchscreens, and that a selection for or against touchscreens must take into consideration the specific context of system interaction in order to maximize safety, performance, and user satisfaction. Our report concludes with a set of specific recommendations for systems designers considering touchscreens as input/output devices, and suggestions for future study into the HFE of touchscreens.