Practicability of protontherapy using compact laser systems

Malka, Victor; Fritzler, S.; Lefebvre, E.; d’Humières, E.; Ferrand, R.; Grillon, G.; Albaret, Claude; Meyroneinc, S.; Chambaret, Jean-Paul; Antonetti, A.; Hulín, D.

doi:10.1118/1.1747751

Cited by 276 publications

(147 citation statements)

References 16 publications

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“…However, there have recently been proposals for low-cost proton treatment facilities where the accelerator is mounted on a gantry and contained in a single room, similar to current x-ray therapy treatment rooms. Some prospects for producing compact designs include laser-induced plasma wakefield accelerators, 4,5 miniaturized cyclotrons, 6 and the dielectric wall accelerator ͑DWA͒. 7 Of paramount importance to the design of all of these accelerators is the maximum proton kinetic energy that must be achieved.…”

Section: Introductionmentioning

confidence: 99%

Maximum proton kinetic energy and patient‐generated neutron fluence considerations in proton beam arc delivery radiation therapy

et al. 2009

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Several compact proton accelerator systems for use in proton therapy have recently been proposed. Of paramount importance to the development of such an accelerator system is the maximum kinetic energy of protons, immediately prior to entry into the patient, that must be reached by the treatment system. The commonly used value for the maximum kinetic energy required for a medical proton accelerator is 250 MeV, but it has not been demonstrated that this energy is indeed necessary to treat all or most patients eligible for proton therapy. This article quantifies the maximum kinetic energy of protons, immediately prior to entry into the patient, necessary to treat a given percentage of patients with rotational proton therapy, and examines the impact of this energy threshold on the cost and feasibility of a compact, gantry-mounted proton accelerator treatment system. One hundred randomized treatment plans from patients treated with IMRT were analyzed. The maximum radiological pathlength from the surface of the patient to the distal edge of the treatment volume was obtained for 180°continuous arc proton therapy and for 180°split arc proton therapy ͑two 90°arcs͒ using CT# profiles from the Pinnacle™ ͑Philips Medical Systems, Madison, WI͒ treatment planning system. In each case, the maximum kinetic energy of protons, immediately prior to entry into the patient, that would be necessary to treat the patient was calculated using proton range tables for various media. In addition, Monte Carlo simulations were performed to quantify neutron production in a water phantom representing a patient as a function of the maximum proton kinetic energy achievable by a proton treatment system. Protons with a kinetic energy of 240 MeV, immediately prior to entry into the patient, were needed to treat 100% of patients in this study. However, it was shown that 90% of patients could be treated at 198 MeV, and 95% of patients could be treated at 207 MeV. Decreasing the proton kinetic energy from 250 to 200 MeV decreases the total neutron energy fluence produced by stopping a monoenergetic pencil beam in a water phantom by a factor of 2.3. It is possible to significantly lower the requirements on the maximum kinetic energy of a compact proton accelerator if the ability to treat a small percentage of patients with rotational therapy is sacrificed. This decrease in maximum kinetic energy, along with the corresponding decrease in neutron production, could lower the cost and ease the engineering constraints on a compact proton accelerator treatment facility.

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Section: Introductionmentioning

confidence: 99%

Maximum proton kinetic energy and patient‐generated neutron fluence considerations in proton beam arc delivery radiation therapy

et al. 2009

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“…This is because the laser-driven energetic ions show many peculiar characteristics compared with those of the ion beams from conventional accelerators [70,71], thus many potential fields of applications are proposed, including medical application [72][73][74]. For the medical applications, there still exist many issues which we have to overcome.…”

Section: Laser-accelerated Protons From Thin Foilsmentioning

confidence: 99%

Ultra-Intense, High Spatio-Temporal Quality Petawatt-Class Laser System and Applications

et al. 2013

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This paper reviews techniques for improving the temporal contrast and spatial beam quality in an ultra-intense laser system that is based on chirped-pulse amplification (CPA). We describe the design, performance, and characterization of our laser system, which has the potential for achieving a peak power of 600 TW. We also describe OPEN ACCESSAppl. Sci. 2013, 3 215 applications of the laser system in the relativistically dominant regime of laser-matter interactions and discuss a compact, high efficiency diode-pumped laser system.

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“…Laser applications are used in proton radiography [1], fast ignition [2], hadrontherapy [3], [4], radioisotope production [5] and laboratory astrophysics [6]. During the laser-target interaction, ions are accelerated by different physical processes, depending on the region of the target.…”

Section: Introductionmentioning

confidence: 99%