Plasmas are an attractive medium for the next generation of particle accelerators because they can support electric fields greater than several hundred gigavolts per meter. These accelerating fields are generated by relativistic plasma waves-space-charge oscillations-that can be excited when a high-intensity laser propagates through a plasma. Large currents of background electrons can then be trapped and subsequently accelerated by these relativistic waves. In the forced laser wake field regime, where the laser pulse length is of the order of the plasma wavelength, we show that a gain in maximum electron energy of up to 200 megaelectronvolts can be achieved, along with an improvement in the quality of the ultrashort electron beam.

Protontherapy is a well-established approach to treat cancer due to the favorable ballistic properties of proton beams. Nevertheless, this treatment is today only possible with large scale accelerator facilities which are very difficult to install at existing hospitals. In this article we report on a new approach for proton acceleration up to energies within the therapeutic window between 60 and 200 MeV by using modern, high intensity and compact laser systems. By focusing such laser beams onto thin foils we obtained on target intensities of 6 x 10(19) W/cm2, which is sufficient to produce a well-collimated proton beam with an energy of up to 10 MeV. These results are in agreement with numerical simulations and indicate that proton energies within the therapeutic window should be obtained in the very near future using such economical and very compact laser systems. Hence, this approach could revolutionize cancer treatment by bringing the "lab to the hospital-rather than the hospital to the lab".

The interaction of short and intense laser pulses with plasmas is a very efficient source of relativistic electrons with tunable properties. In low-density plasmas, we observed bunches of electrons up to 200 MeV, accelerated in the wakefield of the laser pulse. Less energetic electrons (tens of megaelectronvolt) have been obtained, albeit with a higher efficiency, during the interaction with a pre-exploded foil or a solid target. When these relativistic electrons slow down in a thick tungsten target, they emit very energetic Bremsstrahlung photons which have been diagnosed directly with photoconductors, and indirectly through photonuclear activation measurements. Dose, photoactivation, and photofission measurements are reported. These results are in reasonable agreement, over three orders of magnitude, with a model built on laser–plasma interaction and electron transport numerical simulations.