2014
DOI: 10.1016/j.ijpharm.2014.08.016
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Practical approach to prepare solid dispersion drug product using spherical silicate

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Cited by 12 publications
(4 citation statements)
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“…38 It was observed that the extent of conversion increased with increasing drug content. Similar results on the thermal behavior of silicate carriers after loading with increasing drug contents, were reported by Nagane et al [39]. They considered a relationship between the carrier's available surface area and the maximum loadable drug content in the amorphous state, suggesting a threshold above which only partial amorphization occurred.…”
Section: Dsc Studiessupporting
confidence: 82%
“…38 It was observed that the extent of conversion increased with increasing drug content. Similar results on the thermal behavior of silicate carriers after loading with increasing drug contents, were reported by Nagane et al [39]. They considered a relationship between the carrier's available surface area and the maximum loadable drug content in the amorphous state, suggesting a threshold above which only partial amorphization occurred.…”
Section: Dsc Studiessupporting
confidence: 82%
“…Despite their outstanding complexation performance, those methods are characterised by low yield, stability problems and difficulty of scale‐up . In contrast, fluid‐bed (FB) granulation has been widely used in the development and production of solid dosage forms, because it is a fast and versatile process . Solid processing by this method may allow the formation of inclusion complexes simultaneously with the granulation process.…”
Section: Introductionmentioning
confidence: 99%
“…[20,21] In contrast, fluid-bed (FB) granulation has been widely used in the development and production of solid dosage forms, because it is a fast and versatile process. [22] Solid processing by this method may allow the formation of inclusion complexes simultaneously with the granulation process. In spite of that, few studies have explored the use of this technique to produce cyclodextrin inclusion complexes.…”
Section: Introductionmentioning
confidence: 99%
“…Many studies have reported attempts to encapsulate indomethacin and/or indomethacin derivatives, to protect the gastrointestinal (GI) tract against mucosal damage, in systems composed by biodegradable natural (polysaccharides including chitosan, amylose, pectin, starch, guar gum, egg albumin, dextran, and alginate) and synthetic (Eudragits, ethyl cellulose) polymers or their combinations. In addition to the classic but less effective method of tablet coating with pH‐sensitive polymers, different kinds of carriers were used: for example, lipid nanocapsules, magnetic nanoparticles, nanocolloids, granules, beads, and especially microparticles. About these latter, recent interesting techniques, used to indomethacin delivery purposes, are reported in literature.…”
Section: Introductionmentioning
confidence: 99%