Practical bioinstrumentation developments for AC magnetic field-mediated magnetic nanoparticle heating applications

Abstract

Heat dissipation during magnetization reversal processes in magnetic nanoparticles (MNP), upon exposure to alternating magnetic fields (AMF), has been extensively studied in relation to applications in magnetic fluid hyperthermia (MFH). This current paper demonstrates the design, fabrication, and evaluation of three innovative advances in bioinstrumentation research, operating on this principle, for use as (i) a non-contact, in vitro, real-time temperature monitor; (ii) a drug release analysis system (DRAS); and (iii) a high flux density module for AMF-mediated MNP studies. The proposed DRAS is demonstrated by an AMF-mediated drug-release proof-of-principle experiment. Also, the technique described facilitates non-contact temperature measurements of specific absorption rate (SAR) as accurately as temperature measurements using a probe in contact with the sample. Numerical calculations estimating the absolute and root mean squared flux densities, and other MNP-AMF studies suggest that the proposed stacked planar coil module could be employed for calorimetry.

Numerical Model for Magnetic Fluid Hyperthermia in a Realistic Breast Phantom: Calorimetric Calibration and Treatment Planning

“…Novel therapy methods without negative impacts are needed to reduce mortality rates in patients with breast cancer. One such method is magnetic fluid hyperthermia (MFH) in which magnetic nanoparticles (MNPs) dissipate heat during radiofrequency (RF) application [1,2,3,4,5], activating biochemical pathways leading to necrosis or apoptosis [6,7,8,9]. In the past decade, attention has been given to MFH treatment for breast cancer either on its own or in combination with chemotherapy and radiotherapy [10,11,12,13,14].…”

An in vivo coil setup for AC magnetic field-mediated magnetic nanoparticle heating experiments

“…in vivo coil setup does require further development. Nevertheless, such in silico evaluations will provide knowledge to design suitable AMF applicators for AC magnetic field-mediated in vivo MNP heating as demonstrated in this study [29].…”

Nanopartículas de magnetita dopadas com zinco para fins teranósticos: magnetoacustografia e hipertermia magnética

“…Instead, pancake coils can be used to generate strong magnetic fields focused in a sphere volume, co-centered with the coil, which allows selective application of the magnetic field [92,202,237]. Therefore, this format can be considered as an interesting coil geometry in certain conditions [202,237,336]. The coil used in this study was a pancake coil manufactured by 3/16" (∼ 4.76 mm) diameter copper refrigerator tubing isolated with heatshrink tube.…”