Practical considerations about atrial fibrillation and “pill-in-the-pocket” administration

Widened QRS interval and left ventricular systolic depression after propafenone and promazine exposure

“…It works by blocking the fast inward sodium current and slowing the rate of increase of the action potential [16]. Propafenone toxicity manifests mainly with a cardiac impairment in which bradycardia and QRS widening can occur [15,[17][18][19][20]. Promazine is a phenothiazinetype antipsychotic drug (as mesoridazine, chlorpromazine, fluphenazine, perphenazine and triflupromazine) and also blocks sodium channels [21].…”