Practical Considerations and the Intestinal Microbiome in Disease: Antibiotics for IBD Therapy

Fedorak, Richard N.; Ismond, Kathleen P.

doi:10.1159/000443014

Cited by 10 publications

(7 citation statements)

References 49 publications

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“…(61) Here, the use of tricyclic antidepressants was associated with a reduction in symptom burden in these patients. The intestinal microbiome is an attractive target for therapeutic intervention in IBD, and RCTs of antibiotics, (62) probiotics, (63) FMT, (64) and the low FODMAP diet, (65)(66)(67) have been conducted but, with the exception of the low FODMAP diet, these have largely focused on disease activity outcomes rather than IBS-type symptom reporting specifically. In one of these RCTs, (66) a significantly higher proportion of patients reporting IBS-type symptoms who were randomised to receive a low FODMAP diet achieved adequate relief of IBS-type symptoms than was observed in patients randomised to a control diet, with a number needed to treat of 3.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis

Fairbrass

Costantino

Gracie

et al. 2020

The Lancet Gastroenterology & Hepatology

158

138

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Section: Discussionmentioning

confidence: 99%

Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis

Fairbrass

Costantino

Gracie

et al. 2020

The Lancet Gastroenterology & Hepatology

158

138

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“…In the past decades, numerous studies have tried to show a role for the gut microbiota in the development of CD. Indeed, it has been shown that a treatment with antibiotics such as ciprofloxacin or metronidazole is efficient to treat CD patients 38 . It has also been shown that antibiotic use in early childhood is a risk factor for inflammatory bowel disease development in adults 39 .…”

Section: Discussionmentioning

confidence: 99%

AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation

Bretin

Lucas

Larabi

et al. 2018

Sci Rep

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A high prevalence of adherent-invasive E. coli (AIEC) in the intestinal mucosa of Crohn’s disease patients has been shown. AIEC colonize the intestine and induce inflammation in genetically predisposed mouse models including CEABAC10 transgenic (Tg) mice expressing human CEACAM6-receptor for AIEC and eif2ak4−/− mice exhibiting autophagy defect in response to AIEC infection. Here, we aimed at investigating whether gut microbiota modification contributes to AIEC-induced intestinal inflammation in these mouse models. For this, eif2ak4+/+ and eif2ak4−/− mice or CEABAC10 Tg mice invalidated for Eif2ak4 gene (Tg/eif2ak4−/−) or not (Tg/eif2ak4+/+) were infected with the AIEC reference strain LF82 or the non-pathogenic E. coli K12 MG1655 strain. In all mouse groups, LF82 colonized the gut better and longer than MG1655. No difference in fecal microbiota composition was observed in eif2ak4+/+ and eif2ak4−/− mice before infection and at day 1 and 4 post-infection. LF82-infected eif2ak4−/− mice exhibited altered fecal microbiota composition at day 14 and 21 post-infection and increased fecal lipocalin-2 level at day 21 post-infection compared to other groups, indicating that intestinal inflammation developed after microbiota modification. Similar results were obtained for LF82-infected Tg/eif2ak4−/− mice. These results suggest that in genetically predisposed hosts, AIEC colonization might induce chronic intestinal inflammation by altering the gut microbiota composition.

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“…An increasing amount of evidence supports that microbial imbalance in the GI tract influences the development and progression of IBD [61,[73][74][75][76][77][78][79][80]. Considering the key roles of the intestinal microbiota in the pathogenesis of IBD, the following theories have been postulated:…”

Section: Role Of the Microbiome In Ibd: Postulated Theoriesmentioning

confidence: 99%

Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine

2019

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Background: Inflammatory Bowel Disease (IBD) is a multifactorial chronic disease. Understanding only one aspect of IBD pathogenesis does not reflect the complex nature of IBD nor will it improve its clinical management. Therefore, it is vital to dissect the interactions between the different players in IBD pathogenesis in order to understand the biology of the disease and enhance its clinical outcomes. Aims:To provide an overview of the available omics data used to assess the potential mechanisms through which various players are contributing to IBD pathogenesis and propose a precision medicine model to fill the current knowledge gap in IBD.Results: Several studies have reported microbial dysbiosis, immune and metabolic dysregulation in IBD patients, however, this data is not sufficient to create signatures that can differentiate between the disease subtypes or between disease relapse and remission. Conclusions:We summarized the current knowledge in the application of omics in IBD patients, and we showed that the current knowledge gap in IBD hinders the improvements of clinical decision for treatment as well as the prediction of disease relapse. We propose one way to fill this gap by implementing integrative analysis of various omics datasets generated from one patient at a single time point.

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Practical Considerations and the Intestinal Microbiome in Disease: Antibiotics for IBD Therapy

Cited by 10 publications

References 49 publications

Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis

Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis

AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation

Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine

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