Practical Considerations Regarding the Influence of the Menstrual Cycle on Leukocyte Parameters in Clinical Trials

Apseloff, Glen; Bao, Xiaohui; LaBoy-Goral, Lucia; Friedman, H. S.; Shah, Ajit N.

doi:10.1097/00045391-200007050-00005

Cited by 13 publications

(10 citation statements)

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“…Increased in absolute neutrophil count in secretory phase was statistically significant. The highest neutrophil count during secretory was not in agreement with the study by Apseloff G et al 13 A small rise in neutrophil count in menstrual phase when compared to proliferative was in agreement with the results The reason may be that both the luteal phase and pregnancy are associated with a type -2immune response shifting immunity away from the cell mediated immune response. The pregnancy associated changes in the immune response are already observed in the luteal phase.…”

Section: Section: Physiologycontrasting

confidence: 50%

Study of Cyclical Variations of Leukocyte Profile during different Phases of Menstrual Cycle in 1st MBBS Students

Anal¹,

Ningshen²

2019

IJCMR

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Introduction: Menstrual cycle is the periodic shedding of endometrium accompanied by loss of blood during reproductive age.The period extending from the begining of menses to the begining of next one. The regulation of the normal cycle is under the control of neuro hormonal mechanisms with its feedback system present in the hypothalamic-pituitary-ovarian axis. This study was taken up to see the alterations in the immune cells(leukocytes cells) during menstrual cycle in the Medical students of Jawaharlal Institute of Medical sciences.

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Section: Section: Physiologycontrasting

confidence: 50%

Study of Cyclical Variations of Leukocyte Profile during different Phases of Menstrual Cycle in 1st MBBS Students

Anal¹,

Ningshen²

2019

IJCMR

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“…Although the effect of the normal menstrual cycle on the leukocyte counts has frequently been investigated, the results showed no significant increases of leukocyte count around ovulation [21,22,23]. However, examining the data presented in the literature, a mild non-significant increase of leukocyte around ovulation was observed in many studies [21,22].…”

Section: Leukocytes In Ovulation Mechanismmentioning

confidence: 99%

Granulocyte Colony-Stimulating Factor (G-CSF) in the Mechanism of Human Ovulation and its Clinical Usefulness

Makinoda

Hirosaki²,

Waseda³

et al. 2008

CMC

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In 1980, Espey proposed a famous hypothesis that mammalian ovulation is comparable to an inflammatory reaction and many researches have proved the validity of his hypothesis in the last three decades. For example, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)- alpha, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and other inflammatory cytokines presence was proven in the preovulatory follicle. Since granulocyte is the major leukocyte and it plays a very important role during inflammation, the importance of granulocyte and its related cytokine, granulocyte colony-stimulating factor (G-CSF) in the mechanism of human ovulation is easily predictable. G-CSF is one of the hemopoietic cytokines and it has strong positive effects on granulocytes. G-CSF increases the number of granulocytes and it improves the function of granulocytes. In this review, the participation of leukocytes in the ovulation mechanism is demonstrated first. Second, the participation of G-CSF is shown in comparison with the above mentioned cytokines. Finally, since G-CSF has been used for more than 20 years as a medicine without severe side effects in the field of oncology, the clinical application of G-CSF for the treatment of an ovulation disorder, luteinized unruptured follicle (LUF), will be discussed.

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“…The number of granulocytes increases during pregnancy and in the luteal phase in comparison with the follicular phase [37]. This increase has been attributed to the effect of progesterone and estrogens in the bone marrow and to the delay of apoptosis [38].…”

Section: Granulocytesmentioning

confidence: 99%

Sex hormones and autoimmunity

et al. 2010

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Practical Considerations Regarding the Influence of the Menstrual Cycle on Leukocyte Parameters in Clinical Trials

Cited by 13 publications

References 0 publications

Study of Cyclical Variations of Leukocyte Profile during different Phases of Menstrual Cycle in 1st MBBS Students

Study of Cyclical Variations of Leukocyte Profile during different Phases of Menstrual Cycle in 1st MBBS Students

Granulocyte Colony-Stimulating Factor (G-CSF) in the Mechanism of Human Ovulation and its Clinical Usefulness

Sex hormones and autoimmunity

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