Practical Molecular Pathology and Histopathology of Embryonal Tumors

Tihan, Tarık; Fuller, Gregory N.

doi:10.1016/j.path.2014.10.003

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…The majority of cells in the brain vesicle-and nucleus-like structures were small round or elongated (Fig. 2B-a), morphologically similar to undifferentiated tumor cells or neuroepithelial cells that can be seen in medulloblastomas and CNS embryonal tumors (previously designated as primitive neuroectodermal tumors) [8,14]. Other cell types, including ependymal-like cells and astrocyte-like cells, were also present in the graft at a low frequency (Fig.…”

Section: Chimeric Grafts Exhibited Histological Features Of Embryonicmentioning

confidence: 83%

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Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors

Qu-Petersen¹

2016

AJPN

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Unlike totipotent ES cells, adult-origin multipotent progenitors have limited differentiation. Several CNS carcinomas featuring embryonic nervous and muscle tissues, however, suggest the existence of distinct primitive progenitors. Rhabdomyosarcoma is a soft tissue malignant tumor, and although it displays phenotypical features of neural and muscle elements, its etiology remains largely unaddressed. It has been shown that muscle-derived neuroepithelial myogenic progenitors (NEMPs) differentiate into radial glial-like cells, neurons, and early myoblasts in vitro and generate embryonic/fetal-like myofibers in vivo. The present study reports that NEMPs could also generate chimeric grafts in muscle, which exhibited morphogenetic features of the embryonic brain, developing nerve nuclei/ganglia, and primitive striated muscle. A single NEMP differentiated in vitro into multiple colonies containing neuroepithelial cells, neurons, astroglia, and myoblasts, with embryonic tissue patterns. The data demonstrate that generation of embryonic nervous tissues is NEMP's unique potency, providing translational evidence for a NEMP origin of the different malignant neoplasms.

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Section: Chimeric Grafts Exhibited Histological Features Of Embryonicmentioning

confidence: 83%

“…Very few of cells in the area were large round cells ( Fig. 2B-d), resembling rhabdomyoblasts in RMS [11] or rhabdoid cells in AT/RT [14,15]. Outside the neural tube-and nucleus-like structures, many small round cells (Fig.…”

Section: Chimeric Grafts Exhibited Histological Features Of Embryonicmentioning

confidence: 99%

Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors

Qu-Petersen¹

2016

AJPN

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“…The eleventh pitfall or trap; is the distinction between embryonal tumors, germ cell neoplasms, and hematolymphoid malignancies. In particular, medulloblastoma ( Figure 9(a) – 9(f) ) and atypical teratoid/rhabdoid tumor, soft tissue sarcomas can be confused with small cell carcinomas, neuroblastoma, and lymphomas, while embryonal tumors with multilayered rosettes can be confused with lymphomas and anaplastic ependymoma ( Figure 10(a) – 10(f) ) [ 29 , 30 ]. As in all areas of pathology, there are potential pitfalls in the intraoperative neuropathology.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Touch Imprint Cytology of Brain Neoplasms: A Useful High-Diagnostic Tool in 93 Consecutive Cases; Differential Diagnoses, Pitfalls, and Traps

Koyuncuer

2024

Analytical Cellular Pathology

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Introduction. Intraoperative cytological examination of central nervous system (CNS) lesions was first introduced in 1920 by Eisenhardt and Cushing for rapid evaluation of neurosurgical specimens and to guide surgical treatment. It is recognized that this method not only confirms the adequacy of biopsy in CNS samples but also indicates the presence and preliminary diagnosis of lesional tissue. Methods. A total of 93 patients who underwent touch imprint cytology (TIC) for CNS tumors or lesions between 2018 and 2023 were included in the study. All cases were correlated with the final histopathological diagnosis, and pitfalls and difficulties encountered with discrepancies were noted. Result. The most common primary CNS tumors were gliomas and meningiomas, while secondary (metastatic) tumors were predominantly lung, breast, and gastrointestinal system carcinomas. Sensitivity, specificity, positive predictive value, and negative predictive value for diagnosis with TIC were 94.1%, 100%, and 61.5%, respectively. Final histopathological diagnosis by TIC was made in 88 cases (94.6%) and the discrepancy was found in 5 cases (5.37%). Three of the five discrepancies (3.2%) were haematolymphoid malignancies (two lymphomas and one plasma cell neoplasia), one glioblastoma, and one hemangioblastoma case. Conclusion. TIC is a fast, safe, and inexpensive diagnostic tool used during intraoperative neuropathology consultation. Awareness of the pitfalls of using this method during intraoperative consultation will enable high-diagnostic accuracy.

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“…Tumors predominantly composed by structures that recreate features of the primitive neural tube (i.e. tubular, papillary, trabecular, or even glandular-appearing arrangements of primitive cells often with an outer layer) were called Medulloepitheliomas (MEPL) [2,4]. Another rare, variant of CNS -PNET termed Embryonal Tumor with Abundant Neuropils and True Rosettes (ETANTR) is characterized by focal areas of high cellularity, broad bands of neoplastic neuropils and ependymoblastic rosettes [5].…”

Section: Cns Embryonal Tumors (Pnets)mentioning

confidence: 99%

"Medulloepithelioma, An Embryonal Tumor of the Central Nervous System, the Eye and the Optic Nerve: Review of the Clinical Behavior, Cytogenetic and Molecular Characteristics"

Shoag

Cavanaugh

Reichbach

et al. 2020

BJSTR

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Practical Molecular Pathology and Histopathology of Embryonal Tumors

Cited by 8 publications

References 34 publications

Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors

Forming Embryonic-Like Nervous Tissues and Organs by Muscle-Derived Neuroepithelial Myogenic Progenitors

Intraoperative Touch Imprint Cytology of Brain Neoplasms: A Useful High-Diagnostic Tool in 93 Consecutive Cases; Differential Diagnoses, Pitfalls, and Traps

"Medulloepithelioma, An Embryonal Tumor of the Central Nervous System, the Eye and the Optic Nerve: Review of the Clinical Behavior, Cytogenetic and Molecular Characteristics"

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