Prandial Glycaemia After a Carbohydrate-rich Meal in Type I Diabetic Patients: Using the Rapid Acting Insulin Analogue [Lys(B28), Pro(B29)] Human Insulin

Postprandial glycaemia after regular and lispro insulin in children and adolescents with diabetes

“…Several studies in adult patients [4,5] failed to show a signi®cant decrease of the HbA1c levels by using lispro insulin preprandially over a period of 12 months, although there was a signi®cant reduction in frequency of hypoglycaemia [4,5,18]. During puberty and adolescence HbA1c levels increase in most patients [11] due to hormonal as well as psychosocial factors and the tendency to non-compliance [10].…”

Meta-Analysis of the Effect of Insulin Lispro on Severe Hypoglycemia in Patients With Type 1 Diabetes

“…The studies represent all of the large clinical trials in patients with type 1 diabetic patients using insulin lispro that have been performed to date. None of these studies were powered to detect a significant difference in severe hypoglycemia using the strict criteria of the present study We excluded acute pharmacokinetic trials (17)(18)(19)(20)(21)(22)(23)(24)(25)(26), case reports (27)(28)(29), and smaller studies with different objectives or the lack of a control group treated with human soluble insulin (30-33). The total of 233 patients from these small studies was not included in this meta-analysis.…”

Inhaled Insulin and the Lung

“…However, clinical studies have shown that the duration of action of rapid-acting insulin analogues may be too short to provide adequate postprandial control, as indicated by rising glucose levels in the postabsorptive state [129]. In fact, it has been shown that when using insulin analogues, daytime basal insulin therapy was essential in order to improve glycaemic control.…”