Climate changes have been observed all over the world and are pointed out as responsible to impact the natural resources, especially the amount and the quality of the water in a hydrographic basin. Thus, the present research aimed to analyze the variability and trends of air temperature and rainfall data in the Hydrographic Basin of the Ribeirão do Lobo, São Paulo state, Brazil. The weather data from 1988 to 2017 were collected in the Center of Water Resources and Environment Studies of the University of São Paulo (CRHEA), and in five rainfall stations of the National Water Agency of Brazil (ANA) spread all over the basin. To identify climate changes were applied the simple regression, the run test, the Mann-Kendall and modified Mann-Kendall tests. The results showed significant positive trends in air temperature, especially in the annual period and during the third quarter with rising up to 0.068 °C year-1. Significant increases were verified to minimum, maximum and mean air temperature, which suggests possible climate changes during the period in the analysis. To the rainfall data, periods with positive and negative trends were found, although, most of the time the trends were non-significant. However, a significant negative trend of the rainfall was observed in Ribeirão do Feijão station with a reduction of -10.03 mm year-1.