Prävalenz eines polyglandulären Autoimmunsyndroms bei Patienten mit Diabetes mellitus Typ 1

Hunger-Battefeld, W; Fath, Katharina; Mandecka, A.; Kiehntopf, Michael; Kloos, C; Müller, Ulrich A.; Wolf, Günter

doi:10.1007/s00063-009-1030-x

Cited by 23 publications

(13 citation statements)

References 50 publications

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“…Dabei folgt auf einen Diabetes Typ 1 meist eine Autoimmunthyreopathie (3,6 % Prävalenz innerhalb eines Jahres), sodass eine Kombination dieser beiden Erkrankungen auch im Mainzer Patientenkollektiv mit über 50-60 % die häu-figste Manifestation einer adulten APS darstellt. Gleiches gilt auch für Familienmitglieder von Typ-1-Diabetikern, die ein erhöhtes Risiko haben, dass sich eine Autoimmunendokrinopathie, insbesondere eine Autoimmunthyreopathie entwickelt [15]. Die zweithäufigste Erkrankungskombination ist die APS II (M. Addison + Autoimmunendokrinopathie), die besonders bei gemeinsamem Auftreten von einer Autoimmunthyreopathie und/oder eines Typ-1-Diabetes aufgrund von Hormoninteraktionen lebensgefährliche Komplikationen mit sich bringen kann.…”

Section: Klinik Und Diagnostikunclassified

Autoimmune polyglanduläre Syndrome

Hansen¹,

Kahaly²

2013

Dtsch med Wochenschr

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The autoimmune polyglandular syndrome (APS) is defined as the manifestation of at least two endocrine autoimmune diseases. In order to take the wide spectrum of components and the variations of the disease fully into account, APS is usually divided up into the rare juvenile type (APS I) and the more common adult type (APS II-IV). APS I is caused by a monogenetic mutation whereas APS II-IV has a multifactorial genesis with combination related subgroups. Early diagnosis, individual adjustment of therapy and screening of high risk patients in particular are regarded as clinically relevant. In addition to the patient's history, the diagnosis of APS encompasses serologic measurement of organ-specific autoantibodies as well as a clinical examination and functional tests. However, the analysis of immunological modificating, zytokine-coding and tissue-specific genes could also be important within a screening. Although APS is a rather rare disease with an incidence of 1:100 000 (juvenile APS) and 1:20 000 (adult APS), the possibility of an autoimmune polyglandular syndrome should be timely considered. By this means, severe complications can be avoided to some extent and the patients' physical as well as psychological quality of life can be ensured.

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Section: Klinik Und Diagnostikunclassified

Autoimmune polyglanduläre Syndrome

Hansen¹,

Kahaly²

2013

Dtsch med Wochenschr

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“…Furthermore, high incidence of AIT among first-degree relatives of T1D patients points to a significant contribution of genetic factors to immune system failures (see above). (Severinski et al, 2003;Hunger-Battefeld et al, 2009) Noteworthy, the predominant form of AIT in patients of both sexes is hypothyroidism (8.1%), but in males with anti-thyroid Abs AIT is prevalent (85.7% vs 37.5% in females). the total incidence of hypothyroidism in T1D patients with anti-thyroid Abs is 52.2%.…”

Section: T1d and Vaccination: Is There A Correlation Between Them? Thmentioning

confidence: 99%

Preclinical and Predictive Algorithms in Monitoring Patients with Autoimmune Diseases and Their Relatives-at-Risks

Suchkov¹,

Kostyushev²,

Gnatenko³

et al. 2011

Autoimmune Disorders - Current Concepts and Advances From Bedside to Mechanistic Insights

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“…Hunger-Battefeld W. i saradnici su ispitivali prevalencu pojedinih komponenti poliglandularnog autoimunog sindroma kod bolesnika sa diabetes mellitus tip 1 i utvrdili da najveću prevalencu ima autoimuna tireoidna bolest, pri čemu je utvrđena veća prevalenca autotireoidnih antitela nego ispoljenost same bolesti. Takođe je utvrđena veća prevalenca antitela nego same bolesti uzimajući u obzir Addisonovu bolest, pernicioznu anemiju i celijačnu bolest [13]. Ovi bolesnici nisu retki, pominjemo slučaj bolesnice kod koje je u 14. god života dijagnostikovan diabetes mellitus tip 1.…”

Section: Autoimuni Poliglandularni Sindrom Tipunclassified

Autoimunska tireoidna bolest i poliglandularne autoimunske bolesti

Todorović-Dilas¹,

Novakovic-Paro²,

Icin³

et al. 2011

Med gl Ins stit Zlatibor

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Apstrakt: Autoimuni poliglandularni sindrom (PGA) podrazumeva disfunkciju dve ili više endokrinih žlezda, u čijoj osnovi je autoimuni mehanizam. Mnogi autori, pored dva osnovna PGA sindroma, izdvajaju treći koji podrazumeva autoimunu tireoidnu bolest (ATD) udruženu sa drugim autoimunim bolestima. PGA tip 1 se javlja ređe, sa početkom u ranom detinjstvu i ključna je mutacija autoimunog regulator-gena. Tri glavne komponente karakterišu ovaj sindrom: mukokutana kandidijaza, hipoparatireoidizam i autoimuna adrenalna insufi cijencija. PGA tip 2 je povezan sa HLA sistemom antigena i u osnovi je poremećaj CD4+ i CD25+ regulatornih T-ćelija. Glavne komponente sindroma su Addisonova bolest, ATD i tip 1 diabetes mellitus. Bitna karakteristika PGA sindroma je da se ispoljavanje komponenti javlja u različitim vremenskim intervalima sa višegodišnjim međusobnim periodima. ATD je mnogo češća od drugih autoimunih endokrinih bolesti i obuhvata Gravesovu bolest, hronični autoimuni tireoiditis i postpartalni tireoiditis. ATD asocira sa HLA klasom II gena i polimorfi zmom citotoksičnih T-limfocitnih antigena 4. U osnovi je poremećaj celularnog i humoralnog imuniteta sa stvaranjem autoantitela na tkivno specifi čni antigen i prisutnom infi ltracijom mononuklearnih ćelija, dominantno limfocita u afektiranom tkivu. Najčešće su prisutna antitela na tireoidnu peroksidazu, tireoglobulin i TSH receptor. ATD je često udružena sa drugim endokrinim (diabetes mellitus tip 1, Addisonova bolest, autoimune bolesti hipofi ze, hipoparatireoidizam, prevremena ovarijalna insufi cijencija), ali i ne-endokrinim autoimunim bolestima. S obzirom na frekventnost ATD opravdan je skrining na ATD u okviru drugih autoimunih bolesti, a ne * Prof.dr Ljiljana Todorović-Đilas, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Klinički centar Vojvodine, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Hajduk Veljkova 1-3, 21000 Novi Sad, drdjilas@eunet.rs

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Prävalenz eines polyglandulären Autoimmunsyndroms bei Patienten mit Diabetes mellitus Typ 1

Cited by 23 publications

References 50 publications

Autoimmune polyglanduläre Syndrome

Autoimmune polyglanduläre Syndrome

Preclinical and Predictive Algorithms in Monitoring Patients with Autoimmune Diseases and Their Relatives-at-Risks

Autoimunska tireoidna bolest i poliglandularne autoimunske bolesti

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