2016
DOI: 10.1186/s12959-016-0123-z
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Pre-analytical issues in the haemostasis laboratory: guidance for the clinical laboratories

Abstract: Ensuring quality has become a daily requirement in laboratories. In haemostasis, even more than in other disciplines of biology, quality is determined by a pre-analytical step that encompasses all procedures, starting with the formulation of the medical question, and includes patient preparation, sample collection, handling, transportation, processing, and storage until time of analysis. This step, based on a variety of manual activities, is the most vulnerable part of the total testing process and is a major … Show more

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Cited by 103 publications
(120 citation statements)
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“…Storage conditions, storage time and temperature are some of the many variables that can affect the stability of coagulation factors and influence the results of coagulation assays . We studied the stability of aliquoted plasma samples stored at RT for up to 48 hours.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Storage conditions, storage time and temperature are some of the many variables that can affect the stability of coagulation factors and influence the results of coagulation assays . We studied the stability of aliquoted plasma samples stored at RT for up to 48 hours.…”
Section: Discussionmentioning
confidence: 99%
“…Understanding the potential impact of these variables on laboratory results is of great importance. Results affected by pre‐analytical errors can have a significant impact on patient outcomes, such as diagnosis or treatment . The Clinical and Laboratory Standards Institute (CLSI) guidelines (Document H21‐A5) state that whole blood samples or plasma samples, stored at room temperature (RT), for routine haemostasis tests or determination of coagulation factors should be analysed within 4 hours after sample collection, with exception of prothrombin time (PT) testing with stability up to 24 hours .…”
Section: Introductionmentioning
confidence: 99%
“…There are various potential analytical and preanalytical sources of the variation observed here . We attempted to minimize sources of error we could control, including the analyzers, assay consumables, machine operators, and the samples.…”
Section: Discussionmentioning
confidence: 99%
“…Occasionally, spurious results (SR) are observed, which unfortunately can lead to an incorrect diagnosis with harmful consequences . In addition to biologic variation (related to the physiology and pathology of the patient), the cause of SR can come from any facet of the laboratory testing process: Preanalytical Variables (inadequate blood samples, incorrect anticoagulants, inappropriate processing, and/or storage), Analytical and Technical Variables (factors pertaining to the testing methodology), and Postanalytical Variables (incorrect reference interval, misinterpretation by laboratorian or clinician) ).…”
Section: Introductionmentioning
confidence: 99%
“…A good understanding of the sources of laboratory errors aided by the establishment of procedures and policies to eliminate or at least reduce avoidable errors is paramount to good coagulation laboratory operations . Although the laboratory testing process is divided into three stages: preanalytical (including biological variation), analytical, and postanalytical (including interpretation), most SR occur in the preanalytical stage followed by SR in the analytical and postanalytical stages . Each stage has components that must be regulated to ensure a correct result and subsequent interpretation to minimize SR.…”
Section: Introductionmentioning
confidence: 99%