Pre Analytical Phase : The Seismic Zone of Clinical Laboratory Testing

Sareen, Rateesh; Kapil, Menka; Gupta, GN

doi:10.21276/aams.2044

AAMS 2018

DOI: 10.21276/aams.2044

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Pre Analytical Phase : The Seismic Zone of Clinical Laboratory Testing

Rateesh Sareen

Menka Kapil

GN Gupta

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2022

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Determination of Sigma metric based on various TEa sources for CBC parameters: the need for Sigma metrics harmonization

Ozdemir

Uçar

2022

Journal of Laboratory Medicine

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Objectives The application of Sigma metrics can be used for assessing the performance of diagnostic laboratories. Clinical laboratories are confronted with the trouble of having to select the best and suitable quality specifications that are required for quality planning. In this regard, our study aims at evaluating the performance of Sysmex XN-1000 hematology analyzer by using Sigma metrics based on different total allowable error (TEa) source and to determine the effects of these variations in Sigma metric evaluation. Methods Five TEa requirements were selected to calculate Sigma metrics of 11 complete blood count (CBC) parameters. Coefficient of variation (CV) and bias data were supplied from internal quality control (IQC) and External Quality Assessment Scheme (EQAS) respectively. Results According to TEa based on desirable biological variation (BV) database specifications, the highest Sigma value was achieved by White Blood Cell count for each level, the lowest value was achieved by Red Cell Distribution Width-Standard Deviation parameter. The Sigma calculation based on Spanish TEa showed that seven CBC parameter achieved Sigma value ≥3. Conclusions According to the results of the study, it can be concluded that Sigma scores have a significant fluctuation based on which TEa sources are utilized and the need for Sigma metrics harmonization and standardization is highlighted. Additionally, low Sigma values of most CBC parameters are resulted in the conclusion that the use of performance goals depending on BV data is difficult for common clinical use. Therefore, clear standardized criteria are quite necessary for the selection of TEa goal by laboratories.

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Determination of Sigma metric based on various TEa sources for CBC parameters: the need for Sigma metrics harmonization

Ozdemir

Uçar

2022

Journal of Laboratory Medicine

View full text Add to dashboard Cite

show abstract

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Pre Analytical Phase : The Seismic Zone of Clinical Laboratory Testing

Cited by 1 publication

References 11 publications

Determination of Sigma metric based on various TEa sources for CBC parameters: the need for Sigma metrics harmonization

Determination of Sigma metric based on various TEa sources for CBC parameters: the need for Sigma metrics harmonization

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