Pre- and co-treatment with xanthophyll enhances the anti-leukemic activity of adriamycin

Lee, Keyong Ho

doi:10.1016/j.jphotobiol.2008.06.008

Cited by 10 publications

(4 citation statements)

References 31 publications

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“…Yet, free radical-mediated oxidative stress is widely reported in the literature. For example, aerobic metabolism generates various reactive oxygen species (ROS) that can have deleterious effects on cellular macromolecules, including lipids, proteins, and DNA (Lee, 2008). It has been shown that uncontrolled generation of free radicals in the cell is responsible for many pathological conditions, such as ischemic injury, Parkinson's disease, arthritis, myocardial infarction, Alzheimer's, cancer, and arteriosclerosis (Blomhoff, 2005;Matés & Sánchez-Jiménez, 2000).…”

Section: Introductionmentioning

confidence: 99%

Protection of lung fibroblast MRC-5 cells against hydrogen peroxide-induced oxidative damage by 0.1–2.8kDa antioxidative peptides isolated from whey protein hydrolysate

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Protection of lung fibroblast MRC-5 cells against hydrogen peroxide-induced oxidative damage by 0.1–2.8kDa antioxidative peptides isolated from whey protein hydrolysate

et al. 2012

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“…Injection of cerum oxide nanoparticles (nanoceria) has scavenging abilities by mimicking the activities of SOD and catalase and has been shown to inhibit production of ROS, suppress levels of VEGF, and promote prevention and regression of retinal neovascular lesions in a mouse model of AMD [ 109 ]. Lutein, a xanthophyll extract with antioxidant and radical scavenging abilities, has been shown to protect against AMD [ 158 ]. Clearly, ROS scavenging through a variety of mechanisms has the potential for therapeutic efficacy in AMD.…”

Section: Formation Of Reactive Oxygen Species Resulting From Diseamentioning

confidence: 99%

Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina

Rohowetz

Kraus

Koulen

2018

IJMS

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The significance of oxidative stress in the development of chronic neurodegenerative diseases of the retina has become increasingly apparent in recent years. Reactive oxygen species (ROS) are free radicals produced at low levels as a result of normal cellular metabolism that are ultimately metabolized and detoxified by endogenous and exogenous mechanisms. In the presence of oxidative cellular stress, ROS are produced in excess, resulting in cellular injury and death and ultimately leading to tissue and organ dysfunction. Recent studies have investigated the role of excess ROS in the pathogenesis and development of chronic neurodegenerative diseases of the retina including glaucoma, diabetic retinopathy, and age-related macular degeneration. Findings from these studies are promising insofar as they provide clear rationales for innovative treatment and prevention strategies of these prevalent and disabling diseases where currently therapeutic options are limited. Here, we briefly outline recent developments that have contributed to our understanding of the role of ROS in the pathogenesis of chronic neurodegenerative diseases of the retina. We then examine and analyze the peer-reviewed evidence in support of ROS as targets for therapy development in the area of chronic neurodegeneration of the retina.

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“…In vitro studies suggest that light at wavelengths between 625-1000 nm (from red to infrared) when applied alone does not induce increased growth of bacteria such as S. aureus and P. aeruginosa (Lipovsky et al, 2010;Lee et al, 2011;Baffoni et al, 2012;Costa and Assis, 2012;Araujo et al, 2013;Kim et al, 2013;Pereira et al, 2014). This suggests that such wavelengths do not interact with chromophores known to exist in these infectious agents.…”

Section: Discussionmentioning

confidence: 99%

Blue and red light photoemitters as approach to inhibit Staphylococcus aureus and Pseudomonas aeruginosa growth

Galo

Prado²,

Santos

2022

Braz. J. Biol.

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The ability of pathogenic bacteria acquire resistance to the existing antibiotics has long been considered a dangerous health risk threat. Currently, the use of visible light has been considered a new approach to treat bacterial infections as an alternative to antibiotics. Herein, we investigated the antimicrobial effect of two range of visible light, blue and red, on Staphylococcus aureus and Pseudomonas aeruginosa, two pathogenic bacterial commonly found in healthcare settings-acquired infections and responsible for high rate of morbidity and mortality. Bacterial cultures were exposed to blue or red light (470 nm and 660 nm) provided by light-emitting diodes - LED. The fluencies and irradiance used for blue and red light were 284.90 J/cm2, 13.19 mW/cm2 and 603.44 J/cm2, 27.93 mW/cm2 respectively. Different experimental approaches were used to determine the optimal conditions of light application. Only exposure to blue light for 6 hours was able to inhibit about 75% in vitro growth of both bacterial species after 24 hours. The surviving exposed bacteria formed colonies significantly smaller than controls, however, these bacteria were able to resume growth after 48 hours. Blue light was able to inhibit bacterial growth upon inoculation in both saline solution and BHI culture medium. We can conclude that blue light, but not red light, is capable of temporarily retarding the growth of gram negative and gram positive bacteria.

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Pre- and co-treatment with xanthophyll enhances the anti-leukemic activity of adriamycin

Cited by 10 publications

References 31 publications

Protection of lung fibroblast MRC-5 cells against hydrogen peroxide-induced oxidative damage by 0.1–2.8kDa antioxidative peptides isolated from whey protein hydrolysate

Protection of lung fibroblast MRC-5 cells against hydrogen peroxide-induced oxidative damage by 0.1–2.8kDa antioxidative peptides isolated from whey protein hydrolysate

Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina

Blue and red light photoemitters as approach to inhibit Staphylococcus aureus and Pseudomonas aeruginosa growth

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