Pre and post-injury environmental enrichment effects functional recovery following medial frontal cortical contusion injury in rats

Jacqmain, Justin; Nudi, Evan; Fluharty, Sarah; Smith, Jeffrey S.

doi:10.1016/j.bbr.2014.08.056

Cited by 18 publications

(7 citation statements)

References 67 publications

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“…The delicate manipulations of the forelimbs important for the normal life of rodents were analyzed using the sunflower seed task, vermicelli handling test, and the adhesive test, indicative of sensory and motor abilities of the forelimbs, tongue, and jaw [ 42 , 43 , 44 , 45 ]. In hHcy rats impaired manipulation of small objects (seeds, vermicelli) and slowing of the manipulation rate (adhesive test and seed task) was observed which may result from dysfunctions of cortex and subcortical areas responsible for the fine motor control and sensory feedback as also observed in Parkinson disease, cerebral ischemia, or craniocerebral injury [ 44 , 64 , 65 ]. Indeed, homocysteine is an independent risk factor of Parkinson disease with loss of motor control and L-DOPA treatment leads to elevation of the homocysteine level which aggravates dopaminergic neurodegeneration [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress

et al. 2020

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Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids, including homocysteine and exerts neuroprotective effects. An increase of homocysteine during pregnancy impairs fetal growth and development of the offspring due to severe oxidative stress. We analyzed the effects of the H2S donor—sodium hydrosulfide (NaHS) administered to female rats with hyperhomocysteinemia (hHcy) on behavioral impairments and levels of oxidative stress of their offspring. Rats born from females fed with control or high methionine diet, with or without H2S donor injections were investigated. Rats with maternal hHcy exhibit increased levels of total locomotor activity and anxiety, decreased muscle endurance and motor coordination, abnormalities of fine motor control, as well as reduced spatial memory and learning. Oxidative stress in brain tissues measured by activity of glutathione peroxidases and the level of malondialdehyde was higher in rats with maternal hHcy. Concentrations of H2S and the activity and expression of the H2S generating enzyme—cystathionine-beta synthase—were lower compared to the control group. Administration of the H2S donor to females with hHcy during pregnancy prevented behavioral alterations and oxidative stress of their offspring. The acquisition of behavioral together with biochemical studies will add to our knowledge about homocysteine neurotoxicity and proposes H2S as a potential agent for therapy of hHcy associated disorders.

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Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress

et al. 2020

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“…When the results from all three testing paradigms in this study are combined, the data indicate that post-weaning rearing condition has permanently altered locomotor activity. Being exposed to an EE improves motor function in rotor-rod test [16]. It has been proposed that naturalistic exploratory movements in the EE facilitate gross and fine motor skills, stimulating areas of the motor cortex and the cerebellum [23].…”

Section: Anxiety-like Behavior In the Epmmentioning

confidence: 99%

Enduring effects of post-weaning rearing condition on depressive- and anxiety-like behaviors and motor activity in male rats

Mosaferi

Babri

Ebrahimi

et al. 2015

Physiology & Behavior

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“…For example, although animals raised in environmentally enriched conditions typically fare better after subsequent traumatic brain injury compared to animals raised in standard housing conditions, the standard housing elicits better outcomes than enriched housing if applied during the acute recovery period immediately following the trauma. 266 Similarly, initiation of exercise immediately after traumatic brain injury increases signs of inflammation and fails to mitigate the lesion or its neurological sequelae, in contrast to exercise initiated following a 5-week delay posttrauma. 267 These findings further confirm the importance of optimizing hormesis in the temporal dimension.…”

Section: Repetitive Conditioning For Extension Of Biological Resilienmentioning

confidence: 99%

Enhancing and Extending Biological Performance and Resilience

et al. 2018

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Human performance, endurance, and resilience have biological limits that are genetically and epigenetically predetermined but perhaps not yet optimized. There are few systematic, rigorous studies on how to raise these limits and reach the true maxima. Achieving this goal might accelerate translation of the theoretical concepts of conditioning, hormesis, and stress adaptation into technological advancements. In 2017, an Air Force-sponsored conference was held at the University of Massachusetts for discipline experts to display data showing that the amplitude and duration of biological performance might be magnified and to discuss whether there might be harmful consequences of exceeding typical maxima. The charge of the workshop was “to examine and discuss and, if possible, recommend approaches to control and exploit endogenous defense mechanisms to enhance the structure and function of biological tissues.” The goal of this white paper is to fulfill and extend this workshop charge. First, a few of the established methods to exploit endogenous defense mechanisms are described, based on workshop presentations. Next, the white paper accomplishes the following goals to provide: (1) synthesis and critical analysis of concepts across some of the published work on endogenous defenses, (2) generation of new ideas on augmenting biological performance and resilience, and (3) specific recommendations for researchers to not only examine a wider range of stimulus doses but to also systematically modify the temporal dimension in stimulus inputs (timing, number, frequency, and duration of exposures) and in measurement outputs (interval until assay end point, and lifespan). Thus, a path forward is proposed for researchers hoping to optimize protocols that support human health and longevity, whether in civilians, soldiers, athletes, or the elderly patients. The long-term goal of these specific recommendations is to accelerate the discovery of practical methods to conquer what were once considered intractable constraints on performance maxima.

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Pre and post-injury environmental enrichment effects functional recovery following medial frontal cortical contusion injury in rats

Cited by 18 publications

References 67 publications

Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress

Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress

Enduring effects of post-weaning rearing condition on depressive- and anxiety-like behaviors and motor activity in male rats

Enhancing and Extending Biological Performance and Resilience

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