Pre- and Postcontrast 3D Double Inversion Recovery Sequence in Multiple Sclerosis: A Simple and Effective MR Imaging Protocol

Eichinger, Paul; Kirschke, Jan S.; Hoshi, Muna-Miriam; Zimmer, Claus; Mühlau, Mark; Riederer, Isabelle

doi:10.3174/ajnr.a5329

Cited by 10 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Before the present study, Eichinger et al (14) had already reported the feasibility of CE-DIR for MS lesions. In their study, counts of contrast-enhanced lesions were compared between CE-T1W imaging and DIR subtraction.…”

Section: Discussionmentioning

confidence: 77%

“…As a comparison with CE-T1W imaging in qualitative evaluation, the scoring of lesions in the present study was therefore evaluated from an axial slice just above the superior margin of the corpus callosum. Qualitative evaluation was not performed in Eichinger et al's study (14). Although SNR was not evaluated in their study, inferiority of SNR of DIR was demonstrated in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…As a second limitation in the present study, subtracted images using conventional subtracted T1W imaging (CE-T1W imagingpre-contrast T1W imaging) were not evaluated, because pre-contrast T1W imaging was imaged using synthetic MRI. Eichinger et al (14) have already reported the superiority of DIR subtraction compared with conventional subtracted T1W imaging (CE-T1W imagingpre-contrast T1W imaging). As a third limitation, lesions only in the slice just above the superior margin of the corpus callosum were evaluated to simplify analysis in the present study, although many lesions were seen in other areas such as the brain stem and the periventricular regions.…”

Section: Discussionmentioning

confidence: 99%

“…In post-contrast MR examinations, a minimum delay time of 5 min is recommended between gadolinium injection and acquisition of T1W imaging (3). A relatively long acquisition time for DIR could be useful, but few reports have examined the feasibility of post-contrast DIR (CE-DIR) in patients with MS (14,15). Partial or complete signal loss of enhancing MS lesions on CE-DIR has been confirmed.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Contrast-enhanced double inversion recovery sequence for patients with multiple sclerosis: feasibility of subtraction images between pre- and post-contrast images

et al. 2022

View full text Add to dashboard Cite

Background Few reports have examined the feasibility of a post-contrast double inversion recovery (DIR) magnetic resonance (MR) sequence in patients with multiple sclerosis (MS) because of partial or complete signal loss of enhancing MS lesions. Purpose To compare subtracted images of DIR (pre-contrast – post-contrast DIR images) with contrast enhanced T1-weighted (CE-T1W) images in the depiction of contrast enhancement of MS lesions. Material and Methods In total, 27 patients were included. Two neuroradiologists interpreted both images of CE-T1W imaging and subtracted DIR, and interpretation of the images was classified into a score of 1–5 (from 5, definitely superior contrast of lesions on DIR subtraction compared to conventional CE-T1W imaging, to 1, definitely superior contrast of lesions on CE-T1W imaging. The interrater agreement (κ coefficient) was measured. The signal-to-noise ratio (SNR) and contrast-noise-ratio (CNR) of the lesion were compared. Results A significant difference ( P < 0.001) in scoring was seen between conventional CE-T1W imaging (2.1 ± 1.5 with one reviewer and 2.4 ± 1.5 with the other) and DIR subtraction (4.4 ± 1.0 with one reviewer and 4.7 ± 0.8 with the other). SNR from conventional CE-T1W imaging (24.8 ± 14.7) was significantly superior to that from DIR subtraction (4.0 ± 1.0; P < 0.001). CNR in DIR subtraction (326.4 ± 250.0) was significantly superior to that in conventional CE-T1W imaging (0.8 ± 5.5; P < 0.001). For interrater agreement in the evaluation of contrast enhancement of the lesions, κ coefficients were 0.84 for conventional CE-T1W imaging and 0.72 for DIR subtraction. Conclusion Subtracted DIR image enables more obvious contrast enhancement of the MS lesions compared with conventional CE-T1W imaging.

show abstract

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Contrast-enhanced double inversion recovery sequence for patients with multiple sclerosis: feasibility of subtraction images between pre- and post-contrast images

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, several studies have proven its use to assess lesions in other locations. [8][9][10]12 Moreover, the large amount of noise particularly affects subtraction maps as random noise sums up while a large portion of the contrast is cancelled out. As the differences detected in this study are quite subtle, relying on subtraction maps poses the risk of detecting a large number of false-positive findings.…”

mentioning

confidence: 99%

Acceleration of Double Inversion Recovery Sequences in Multiple Sclerosis With Compressed Sensing

et al. 2019

View full text Add to dashboard Cite

Objective: The aim of this study was to assess the performance of double inversion recovery (DIR) sequences accelerated by compressed sensing (CS) in a clinical setting. Materials and Methods: We included 106 patients with MS (62 female [58%]; mean age, 44.9 ± 11.0 years) in this prospective study. In addition to a full magnetic resonance imaging protocol including a conventional SENSE accelerated DIR, we acquired a CS DIR (time reduction, 51%). We generated subtraction maps between the two DIR sequences to visualize focal intensity differences. Two neuroradiologists independently assessed these maps for intensity differences, which were categorized into definite MS lesions, possible lesions, or definite artifacts. Counts of focal intensity differences were compared using a Wilcoxon rank sum test. Moreover, conventional lesion counts were acquired for both sequences in independent readouts, and agreement between the DIR variants was assessed with intraclass correlation coefficients. Results: No hyperintensity that was rated as definite lesion was missed in the CS DIR. Two possible lesions were only detected in the conventional DIR, one only in the CS DIR (no significant difference, P = 0.57). The conventional DIR showed significantly more definite artifacts within the white matter (P = 0.024) and highly significantly more at the cortical-sulcal interface (P < 0.001). For both readers, intraclass correlation coefficient between the lesion counts in the two DIR variants was near perfect (0.985 for reader 1 and 0.981 for reader 2). Conclusions: Compressed sensing can be used to substantially reduce scan time of DIR sequences without compromising diagnostic quality. Moreover, the CS accelerated DIR proved to be significantly less prone to imaging artifacts.

show abstract

Predicting the apolipoprotein E ε4 allele carrier status based on gray matter volumes and cognitive function

Kim,

Tian,

Jung

et al. 2024

Brain and Behavior

View full text Add to dashboard Cite

BackgroundApolipoprotein E (ApoE) ε4 carriers have a higher risk of developing Alzheimer's disease (AD) and show brain atrophy and cognitive decline even before diagnosis.ObjectiveTo predict ApoE ε4 status using gray matter volume (GMV) obtained from magnetic resonance imaging images and demographic data with machine learning (ML) methods.MethodsWe recruited 74 participants (25 probable AD, 24 amnestic mild cognitive impairment, and 25 cognitively normal older people) with known ApoE genotype (22 ApoE ε4 carriers and 52 noncarriers) and scanned them with three‐dimensional (3D) T1‐weighted (T1W) and 3D double inversion recovery (DIR) sequences. We extracted GMV from regions of interest related to AD pathology and used them as features along with age and mini–mental state examination (MMSE) scores to train different ML models. We performed both receiver operating characteristic curve analysis and the prediction analysis of the ApoE ε4 carrier with different ML models.ResultsThe best model of ML analyses was a cubic support vector machine (SVM3) that used age, the MMSE score, and DIR GMVs at the amygdala, hippocampus, and precuneus as features (AUC = .88). This model outperformed models using T1W GMV or demographic data alone.ConclusionOur results suggest that brain atrophy with DIR GMV and cognitive decline with aging can be useful biomarkers for predicting ApoE ε4 status and identifying individuals at risk of AD progression.

show abstract

Pre- and Postcontrast 3D Double Inversion Recovery Sequence in Multiple Sclerosis: A Simple and Effective MR Imaging Protocol

Abstract: Pre- and postcontrast double inversion recovery enables better detection of contrast-enhancing lesions in MS in the brain compared with T1WI and may be considered an alternative to the standard MR imaging protocol.

Cited by 10 publications

References 19 publications

Contrast-enhanced double inversion recovery sequence for patients with multiple sclerosis: feasibility of subtraction images between pre- and post-contrast images

Contrast-enhanced double inversion recovery sequence for patients with multiple sclerosis: feasibility of subtraction images between pre- and post-contrast images

Acceleration of Double Inversion Recovery Sequences in Multiple Sclerosis With Compressed Sensing

Predicting the apolipoprotein E ε4 allele carrier status based on gray matter volumes and cognitive function

Contact Info

Product

Resources

About