Pre-B cell leukemia associated with chromosome translocation 1;19

Abstract

Chromosome banding studies on 60 children with acute lymphocytic leukemia (ALL), including “null,” pre-B, B, and T cell phenotypes, were performed. In 4 of 17 patients with pre-B cell ALL, we noted a previously undescribed chromosome translocation, t(1;19)(q23;q13). This translocation was not found in patients with “null” cell, B cell, or T cell ALL. Since each patient with the 1;19 translocation experienced early treatment failure, t(1;19)(q23;q13) may mark a subgroup of patients with pre-B cell ALL who have an especially poor prognosis.

The Leukaemia Research Fund/United Kingdom Cancer Cytogenetics Group Karyotype Database in acute lymphoblastic leukaemia: a valuable resource for patient management

“…The translocation, t(1;19)(q23;p13) was first described in 1984 (122) and is strongly associated with a pre-B immunophenotype, ALL-L1 morphology with blasts expressing cytoplasmic immunoglobulin (25). It was reported as one of the most common recurring translocations in childhood ALL, with a frequency of 5-6% overall, but is found specifically in 25% of pre-B ALL (123).…”

Enhanced insulin‐receptor tyrosine kinase activity associated with chromosomal translocation (1;19) in a pre‐B‐cell leukemia line

“…Pre-B-cell leukemia is an acute lymphoblastic leukemia involving cells of the B-cell lineage which produce cytoplasmic but not cell-surface immunoglobulin heavy chains (Vogler et al, 1978). A specific chromosome rearrangement, the translocation t(1;19)(q23;p13.3), occurs in 25% of pre-B-cell leukemias (Carroll et al, 1984). Translocations may result in activation of proto-oncogenes situated near the breakpoints on either chromosome (reviewed by Cory, 1986); specific examples include activation of c-myc with t(8;14) in Burkitt lymphoma (Nishikura et al, 1983), bcl with t(14;18) in follicular lymphoma (Tsujimoto et al, 1984) and c-abl with t(9;22) in chronic myelogenous leukemia (Shtivelman et al, 1985).…”

Translocation (1;5)(q23;q33) in adult acute non‐lymphocytic leukemia

“…It is of interest to note that the DNA segment of chromosome 1 involved in this new translocation is identical to the one involved in t(1;19)(q23;p13.3). Juxtaposition of the lq23 + qter DNA segment to band 19~13.3 has been reported only in patients with pre-B cell acute lymphoblastic leukemia (13,14,15).…”