Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal

Peres, Gonçalo Miguel; Mariana, Melissa; Cairrão, Elisa

doi:10.3390/jcdd5010003

Cited by 85 publications

(78 citation statements)

References 64 publications

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“…The ACOG revised guidelines define preeclampsia as a de-novo and abrupt onset persistent hypertension associated with proteinuria or pathological edema or thrombocytopenia or impaired liver or kidney function or new onset of cerebral or visual disturbances (1,5). Eclampsia is defined as preeclampsia with sudden development of seizures or coma during the gestational or postpartum period, non-attributable to other neurological diseases that justify the convulsive state (6). Globally, preeclampsia is a leading cause of maternal and infant illness and mortality claiming up to 76,000 maternal and 500,000 infant deaths per year, according to conservative estimates (7).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of total LDH and its isoenzymes as markers in preeclampsia

Fazal

Chandru

Biswas

2019

Journal of Medical Biochemistry

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Summary Background Preeclampsia, a rapidly progressing pregnancy-specific multi-systemic syndrome is globally the leading cause of maternal and neonatal morbidity and mortality. This study aims to evaluate the serum total Lactate dehydrogenase levels in women with preeclampsia when compared to normotensive pregnant women and assess the electrophoretic pattern of the LDH isoenzymes in normal pregnancy, preeclampsia and eclampsia. Methods The study, carried out in the Department of Biochemistry of MVJ Medical College, included 30 patients of preeclampsia and 30 normotensive gestational age-matched pregnant women admitted to the Department of OBG. Serum total LDH was analysed by DGKC method. Serum and cord blood samples for isoenzyme distribution analysis were collected from a normal pregnant woman undergoing delivery, a woman with mild eclampsia, two women with eclampsia, and analysed by slab gel electrophoresis followed by activity staining. Results LDH was significantly elevated in cases as well as between the case (mild and severe) groups, showed a moderate positive statistically significant correlation with systolic, diastolic blood pressure and a sensitivity of 50% and a specificity of 80%. Further, the isoenzyme pattern showed a decreasing distribution of aerobic forms of LDH in preeclampsia-eclampsia. Conclusions Preeklampsija, multisistemski sindrom koji brzo napreduje zbog trudnoće, vodeći je uzrok morbiditeta i mortaliteta majki i novoro|enčadi. Ova studija ima za cilj da proceni nivo ukupne laktat dehidrogenaze u serumu kod žena sa preeklampsijom u poređenju sa normotenzivnim trudnicama i proceni elektroforetski obrazac LDH izoenzima u normalnoj trudnoći, preeklampsiji i eklampsiji.

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Section: Introductionmentioning

confidence: 99%

Evaluation of total LDH and its isoenzymes as markers in preeclampsia

Fazal

Chandru

Biswas

2019

Journal of Medical Biochemistry

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“…Further, a study by Purnima and Sonal and another study by Munde et al also concludes that LDH and GGT can be effectively used as biochemical markers as it reflects the severity of preeclampsia and maybe helpful in its management [31,32]. Neha V Bhave further claims that LDH effectively predicts maternal and perinatal outcomes along with the severity of the disease [17].…”

Section: Discussionmentioning

confidence: 96%

“…Hypertensive disorders of pregnancy, characterized by heterogenous clinical and laboratory manifestations and varied pathogenesis, are one of the leading causes of maternal and neonatal morbidity and mortality [17,18]. In the era of laboratory guided diagnosis, laboratory assessment is gaining momentum in evaluation of HDPs.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Laboratory Derangements in Preeclampsia: Revisiting Traditional Biomarkers

Fazal¹,

Chandru²,

Biswas³

2019

SIJB

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Objectives:To assess the routine laboratory analytes, serum Thyroid Stimulating Hormone (TSH), Lactate Dehydrogenase (LDH) and Uric acid in women with preeclampsia compared to normotensive healthy pregnant women and to determine the concentration of liver enzymes in women with preeclampsia. Materials and Methods: The study was carried out in the Department of Biochemistry of MVJ Medical College and Research Hospital. Thirty women with preeclampsia and thirty normotensive pregnant women admitted to the Department of OBG were recruited for the study. Blood samples were collected and analysed for serum TSH, LDH, uric acid and liver enzymes. Mann Whitney U test was employed to evaluate the significance of the differences obtained between the groups. Results: All three analytes were significantly higher in the case group when compared to controls. LDH and ALT (Alanine transaminase) showed significant difference even within the mild and severe preeclampsia groups. A moderate positive statistically significant correlation (r=0.348, p=0.006) was obtained between serum TSH and LDH. Serum TSH level showed a sensitivity of 66.64%, specificity of 73.33% and a positive predictive value of 71.4%. A De Ritis ratio of 1.82 was observed in preeclampsia. Conclusion: TSH, LDH and Uric acid showed significant elevation in preeclampsia. TSH and LDH levels showed a positive correlation. Hence, TSH, LDH and Uric acid could serve as markers of preeclampsia. A hypothyroid status in early pregnancy might be seen as a risk factor for preeclampsia. An elevated ALT and a high De Ritis might indicate an underlying liver and cardiac compromise in preeclampsia.

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“…1| Jan -Apr 2019 eclampsia, where procedures and surgery are performed as indicated by severe preeclampsia. 8,9 Previous research on preeclampsia showed low placental energy status either due to impaired glycolysis, ischemia caused by decreased maternal placental blood flow, or both, and is responsible for fetal growth restriction. 10 The presence of these abnormalities causes significant metabolic abnormalities in the placenta of pregnant women who experience severe preeclampsia and are thought to contribute to disturbances of other metabolic functions, including metabolic functions of blood glucose, lipid, and protein.…”

Section: Original Articlementioning

confidence: 99%

Settings The Role of Low Blood Glucose Level of Mothers with Severe Preeclampsia in Fetal Growth Restriction: a Mini-Study

Prameswari

2019

Indones J Kidney Hypertens

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Background. The number of patients with severe preeclampsia continues to increase worldwide. Blood glucose is significantly decreased in severe preeclampsia patients, starting at the sudden onset of high blood pressure. This depicts the state of low placental energy status in preeclampsia patients with intrauterine growth restriction (IUGR), due to either glycolysis or ischemia disorders resulting from decreased maternal placental blood flow. Aim. To observe the relationship between mother's random blood glucose level with fetal growth restriction complications during acute onset of severe preeclampsia. Methods. A cross-sectional study, random sampling involving twenty-one pregnant women with severe preeclampsia who underwent cesarean section at Permata Bunda Hospital, Malang, Indonesia. Data were taken from medical records, which included: mother's random blood glucose, blood pressure, proteinuria, and complete blood count. Fetal data includes body weight and length. The data were obtained at the subjects' initial admission in the emergency room during the acute phase of the preeclampsia. Result. Maternal blood glucose had a negative and significant relationship with systolic blood pressure (r =-0.843, p < 0.0001) and with newborn body weight (r = 0.465, p = 0.034) in the acute onset of severe preeclampsia. Conclusion. The blood glucose level of patients at the acute onset of preeclampsia is inversely correlated with systolic blood pressure. The blood glucose level is also correlated with fetal weight. However, due to the chronic nature of IUGR, future studies should analyze the relationship between blood glucose, blood pressure, and fetal growth through multiple stages of pregnancy.

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Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal

Cited by 85 publications

References 64 publications

Evaluation of total LDH and its isoenzymes as markers in preeclampsia

Evaluation of total LDH and its isoenzymes as markers in preeclampsia

Assessment of Laboratory Derangements in Preeclampsia: Revisiting Traditional Biomarkers

Settings The Role of Low Blood Glucose Level of Mothers with Severe Preeclampsia in Fetal Growth Restriction: a Mini-Study

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