Summary
Background
Preeclampsia, a rapidly progressing pregnancy-specific multi-systemic syndrome is globally the leading cause of maternal and neonatal morbidity and mortality. This study aims to evaluate the serum total Lactate dehydrogenase levels in women with preeclampsia when compared to normotensive pregnant women and assess the electrophoretic pattern of the LDH isoenzymes in normal pregnancy, preeclampsia and eclampsia.
Methods
The study, carried out in the Department of Biochemistry of MVJ Medical College, included 30 patients of preeclampsia and 30 normotensive gestational age-matched pregnant women admitted to the Department of OBG. Serum total LDH was analysed by DGKC method. Serum and cord blood samples for isoenzyme distribution analysis were collected from a normal pregnant woman undergoing delivery, a woman with mild eclampsia, two women with eclampsia, and analysed by slab gel electrophoresis followed by activity staining.
Results
LDH was significantly elevated in cases as well as between the case (mild and severe) groups, showed a moderate positive statistically significant correlation with systolic, diastolic blood pressure and a sensitivity of 50% and a specificity of 80%. Further, the isoenzyme pattern showed a decreasing distribution of aerobic forms of LDH in preeclampsia-eclampsia.
Conclusions
Preeklampsija, multisistemski sindrom koji brzo napreduje zbog trudnoće, vodeći je uzrok morbiditeta i mortaliteta majki i novoro|enčadi. Ova studija ima za cilj da proceni nivo ukupne laktat dehidrogenaze u serumu kod žena sa preeklampsijom u poređenju sa normotenzivnim trudnicama i proceni elektroforetski obrazac LDH izoenzima u normalnoj trudnoći, preeklampsiji i eklampsiji.
Background: Rabies is 100% fatal zoonotic disease. In India majority of the disease is caused by bite of dogs, whereas bite of several other animals like cats, donkeys, monkeys, pigs, jackals and wolves can cause rabies. Post exposure prophylaxis (PEP) effectively prevents the occurrence of rabies in the exposed person. Hence the current study is done to know the treatment compliance among the patients attending Anti rabies clinic.Methods: It is hospital based longitudinal study. Data was collected through personal interview from January 1st 2013 to December 31st 2013 and clinical examination was done. All patients were registered and were given first dose of ARV at the time of registration and advised to take all the remaining doses as per schedule. Data regarding their compliance for completion of vaccination schedule was analyzed. Statistical analysis was done by using simple proportions and percentages.Results: Out of 7205 patients, 5343 (74.15%) patients completed second dose, 5021 (69.68%) patients completed third dose and 2998 (41.6%) patients completed fourth dose of intradermal schedule of rabies vaccination and anti-rabies immunoglobulins were advised for 1536 patients among them 1180 (76.82%) patients took immunoglobulins.Conclusions: Most of the patients are not completing ARV intradermal schedule. Hence the animal bite patients should be motivated effectively through health education by interpersonal communication at the time of initiation of vaccination course about timely and complete administration of anti - rabies vaccination to attain the goal of Rabies free India.
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