Pre-emptive oral ribavirin therapy of paramyxovirus infections after haematopoietic stem cell transplantation: a pilot study

Abstract

Summary:Infections with the paramyxoviruses, respiratory syncytial virus (RSV) and parainfluenza virus (PIV) can result in serious morbidity and mortality after haemopoietic stem cell transplant (HSCT). Once pneumonia develops, the outcome of these infections is often poor despite anti-viral therapy. Aerosolised ribavirin has been evaluated as pre-emptive therapy for post-transplant RSV infections with some success. Due to the financial and logistic burden involved with the use of aerosolised ribavirin, we explored the efficacy and toxicity of oral ribavirin for pre-emptive therapy of post-transplant RSV and PIV infections in a dose escalating schedule (15-60 mg/kg/day). Five episodes each of RSV and PIV were treated in seven patients. Five patients were receiving treatment for GVHD and two acquired the infection in the pre-engraftment period. All the episodes of RSV infection improved with oral ribavirin with dose escalation to 30-45 mg/kg in three of them. On the other hand, only two of the five PIV infections improved with oral ribavirin. Of the three non-responders, two infections were acquired in the pre-engraftment period with one death from PIV pneumonia. Reversible anaemia was the only side-effect noted in patients treated for over 2 weeks. Thus, the use of oral ribavirin was well tolerated in the post-transplant period with no untoward toxicities. There was a trend towards better response in RSV infections, which needs to be further explored in controlled studies. Bone Marrow Transplantation (2001) 28, 759-763.

Oral ribavirin for treatment of respiratory syncitial virus and parainfluenza 3 virus infections post allogeneic haematopoietic stem cell transplantation

“…Of note, even within these guidelines, dose recommendations for oral RBV were based upon data from one retrospective single-centre study incorporating palivizumab in the treatment schedule. 17 Given the overall limited literature available on efficacy of oral RBV in a post-HPCT setting, 8,12,17,22,27 we believe that exploring different RBV dosing schedules is reasonable.…”

Parainfluenza Viruses

“…Similarly, ribavirin has both in vitro and in vivo activity against HPIV (32,326). Furthermore, there have been anecdotal reports of decreased HPIV shedding and clinical improvement when infected immunocompromised patients were treated with aerosolized and oral ribavirin (41,42,227,336). However, a recent review at Fred Hutchinson Cancer center demonstrated that established HPIV-3 pneumonias responded poorly to aerosolized ribavirin (267).…”

Management of RSV infections in adult recipients of hematopoietic stem cell transplantation

“…However, the use of oral ribavirin has often been associated with the development of anemia, which is usually reversible with no delay in engraftment, and with nausea. 20,71 Hemolysis with subsequent hyperbilirubinemia and leukopenia were reported with the use of IV ribavirin. 1,4,25,60 Moreover, absorption of oral ribavirin in …”