Radio-isotopes produced via proton induced reaction holds special significance regarding nuclear medicine, astrophysical p-process, theragnostic and diagnostic processes. 76 Br, 80m Br and 61 Cu are positron emitter and they are useful in the functional studies via Positron Emission Tomography (PET), whereas 77 Br bears the potential for the application in Single Photon Emission Computed Tomography (SPECT) which involves electron capture process. PET and SPECT have been in high application in medical physics, diagnostics, therapy and nuclear medicine. 99m Tc and 64 Cu are two popular radionuclide which play important role in nuclear medicine, currently being used in bio-medical physics, bone scan, modern imaging, blood pool leveling, oncology and diagnosis of copper related diseases. This paper focus on the generation of recommended nuclear reaction cross sections for the production of some useful medical radio-isotopes using the experimental datasets obtained from EXFOR database and simulated datasets from nuclear reaction model codes TALYS-1.95 and EMPIRE-3.1.1. 95% confidence interval has been implemented to ensure confidence and precision.