Pre-formulation and delivery strategies for the development of bacteriocins as next generation antibiotics

Flynn, James; Ryan, Aoibhín; Hudson, Sarah P.

doi:10.1016/j.ejpb.2021.05.015

Cited by 28 publications

(19 citation statements)

References 213 publications

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“…The accumulated organic acids may act as antimicrobial agents, whereas various bacterial strains present in kefir can produce other antagonistic substances, such as bacteriocins. Bacteriocins have been documented to interfere with the adherence of pathogenic bacteria and potentially contribute to the immune responses of gut health and they are currently being promoted as next-generation antibiotics [12,60].…”

Section: Yeastmentioning

confidence: 99%

“…Probiotic strains, contained in adequate amounts in kefir beverages, have been proposed as effective agents which boost the immune system and may contribute as a biological defence weapon to flatten the curve of the COVID-19 pandemic [12,62]. Specifically, various probiotic strains have been proposed as significant dietary supplements against viral infections, as they provide immunomodulating compounds such as lipoteichoic acid, peptidoglycans, and nucleic acids, as well as favoring the development of bacteriocins, lactic acid, and hydrogen peroxide as antiviral agents [12,60].…”

Section: Kefir Beverages As Protective Dietary Supplements Against Viral Infectionsmentioning

confidence: 99%

“…Another significant outcome provided by these bioactive metabolites is their immunomodulatory and antiviral effects [64]. Particularly, bioactive peptides have been reported to suppress viral activity, boosting the consumer's immune system via the disruption of viral adhesion [12,60,64]. Likewise, bacteriocins produced by probiotic bacteria can be explored as inhibitors of key targets identified for the screening of metabolites for anti-COVID-19 therapeutics [60,65].…”

Section: Kefir Beverages As Protective Dietary Supplements Against Viral Infectionsmentioning

confidence: 99%

“…Particularly, bioactive peptides have been reported to suppress viral activity, boosting the consumer's immune system via the disruption of viral adhesion [12,60,64]. Likewise, bacteriocins produced by probiotic bacteria can be explored as inhibitors of key targets identified for the screening of metabolites for anti-COVID-19 therapeutics [60,65]. For instance, nisin is a well-known bacteriocin that was initially identified in fermented milk and belongs to the group of peptide antimicrobials collectively called type-A (I) lantibiotics [13,66].…”

Section: Kefir Beverages As Protective Dietary Supplements Against Viral Infectionsmentioning

confidence: 99%

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Kefir as a Functional Beverage Gaining Momentum towards Its Health Promoting Attributes

et al. 2021

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The consumption of fermented foods posing health-promoting attributes is a rising global trend. In this manner, fermented dairy products represent a significant subcategory of functional foods with established positive health benefits. Likewise, kefir—a fermented milk product manufactured from kefir grains—has been reported by many studies to be a probiotic drink with great potential in health promotion. Existing research data link regular kefir consumption with a wide range of health-promoting attributes, and more recent findings support the link between kefir’s probiotic strains and its bio-functional metabolites in the enhancement of the immune system, providing significant antiviral effects. Although it has been consumed for thousands of years, kefir has recently gained popularity in relation to novel biotechnological applications, with different fermentation substrates being tested as non-dairy functional beverages. The present review focuses on the microbiological composition of kefir and highlights novel applications associated with its fermentation capacity. Future prospects relating to kefir’s capacity for disease prevention are also addressed and discussed.

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Section: Yeastmentioning

confidence: 99%

Section: Kefir Beverages As Protective Dietary Supplements Against Viral Infectionsmentioning

confidence: 99%

Section: Kefir Beverages As Protective Dietary Supplements Against Viral Infectionsmentioning

confidence: 99%

Section: Kefir Beverages As Protective Dietary Supplements Against Viral Infectionsmentioning

confidence: 99%

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Kefir as a Functional Beverage Gaining Momentum towards Its Health Promoting Attributes

et al. 2021

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“…While bacteriocins typically exhibit selective and target-specific antagonistic activity [ 23 ], the latter group comprise molecules that generally act rather aspecifically in inhibiting the growth of competitor species ( Figure 1 ). Taking into account the worldwide healthcare emergency of the increasing (multi) drug resistance of infectious agents, the antimicrobials produced by probiotic lactobacilli, especially bacteriocins, may be suitable alternatives to conventional antibiotics and thus hold great potential in several biomedical applications [ 18 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Bioprospecting Antimicrobials from Lactiplantibacillus plantarum: Key Factors Underlying Its Probiotic Action

Rocchetti

Russo

Capozzi

et al. 2021

IJMS

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Lactiplantibacillus plantarum (L. plantarum) is a well-studied and versatile species of lactobacilli. It is found in several niches, including human mucosal surfaces, and it is largely employed in the food industry and boasts a millenary tradition of safe use, sharing a long-lasting relationship with humans. L. plantarum is generally recognised as safe and exhibits a strong probiotic character, so that several strains are commercialised as health-promoting supplements and functional food products. For these reasons, L. plantarum represents a valuable model to gain insight into the nature and mechanisms of antimicrobials as key factors underlying the probiotic action of health-promoting microbes. Probiotic antimicrobials can inhibit the growth of pathogens in the gut ensuring the intestinal homeostasis and contributing to the host health. Furthermore, they may be attractive alternatives to conventional antibiotics, holding potential in several biomedical applications. The aim of this review is to investigate the most relevant papers published in the last ten years, bioprospecting the antimicrobial activity of characterised probiotic L. plantarum strains. Specifically, it focuses on the different chemical nature, the action spectra and the mechanisms underlying the bioactivity of their antibacterial and antiviral agents. Emerging trends in postbiotics, some in vivo applications of L. plantarum antimicrobials, including strengths and limitations of their therapeutic potential, are addressed and discussed.

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Bacteriocins of Lactic Acid Bacteria as a Potential Antimicrobial Peptide

Kumar,

Ruhal,

Kataria

2023

Biomimicry Materials and Applications

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Pre-formulation and delivery strategies for the development of bacteriocins as next generation antibiotics

Cited by 28 publications

References 213 publications

Kefir as a Functional Beverage Gaining Momentum towards Its Health Promoting Attributes

Kefir as a Functional Beverage Gaining Momentum towards Its Health Promoting Attributes

Bioprospecting Antimicrobials from Lactiplantibacillus plantarum: Key Factors Underlying Its Probiotic Action

Bacteriocins of Lactic Acid Bacteria as a Potential Antimicrobial Peptide

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