Pre-Lens Tear Meniscus Height, Lipid Layer Pattern and Non-Invasive Break-Up Time Short-Term Changes with a Water Gradient Silicone Hydrogel Contact Lens

Abstract

To evaluate pre-lens tear film volume, stability and lipid interferometry patterns with a silicone hydrogel water content contact lens, a novel, noninvasive, ocular-surface-analyzer technology was used. A prospective, longitudinal, single-center, self-control study was performed in daily or monthly replacement silicone hydrogel contact lens wearers. A tear film analysis was achieved with the Integrated Clinical Platform (ICP) Ocular Surface Analyzer (OSA) from SBM System. The subjects were reassessed, with the contact lens, after 30 min of wearing to quantify the volume, stability and lipid pattern of the short-term pre-lens tear film. Lipid layer thickness decreased from 2.05 ± 1.53 to 1.90 ± 1.73 Guillon patterns (p = 0.23). First pre-lens NIBUT decreased from 5.03 ± 1.04 to 4.63 ± 0.89 s (p = 0.01). Mean pre-lens NIBUT significantly increased from 15.19 ± 9.54 to 21.27 ± 11.97 s (p < 0.01). Lid opening time significantly increased from 26.36 ± 19.72 to 38.58 ± 21.78 s (p < 0.01). The silicone hydrogel contact lens with water gradient technology significantly increased the mean pre-lens NIBUT and lid opening time. Lehfilcon A suggested an improvement in contact lens wearers with tear film instability or decreased subjective symptoms of dry eye disease.

Assessing neophyte response to daily disposable silicone hydrogel contact lenses: A randomised clinical trial investigation over one month

“…41 Despite the fact that FBUT and non-invasive tear break-up time (NIBUT) are both techniques to measure the stability of the tear film, and their values are not interchangeable, a reduction in both parameters has been found after CL use. 16,41 Additionally, the disruption of the tear film layers did not seem to affect the lipid layer thickness, regardless of the wearing time or CL material, as reported in both the present study and previous investigations. 16 A newly developed contact lens material (verofilcon A), composed of a core of silicone-hydrogel material having a water content of 33% and an outer surface with an 80% water content, showed good pre-CL NIBUT values during lens wear, when compared with other daily disposable silicone-hydrogel and hydrogel CLs.…”

“…13 The use of CLs also alters tear film stability and tear volume, with decreased values being observed after CL removal. [14][15][16] Following the suggestion made by the TFOS CLD workshop, this randomised clinical trial aimed to assess the impact of a daily disposable silicone-hydrogel CL (somofilcon A) on symptoms, tear film dynamics and ocular surface integrity, when compared with non-CL wearers over the course of a month, paying special attention to changes in LWE and its potential implications for CLD.…”

Short‐term tear film stability, optical quality and visual performance in two dual‐focus contact lenses for myopia control with different optical designs

“…6 These theoretical predictions were recently confirmed in a clinical study, which demonstrated that Lehfilcon A wear resulted in a significant change in mean (±SD) pre-lens NIBUT from 15.19 ± 9.54 to 21.27 ± 11.97 s (p < 0.01). 7 Further confirmation of these theoretical expectations was provided by Fujimoto et al, 8 where the pre-lens TF with Delefilcon A (θ ≤ 20°) remained stable at 4.1 ± 2.3 s versus Narafilcon A (θ = 70°) with a value of 2.7 ± 1.6 s after ≥5 h wear for 1 month. 5,6 Lateral shearing interferometry also demonstrated higher TF surface quality for Delefilcon A compared with Narafilcon A (a hydrogel lens with higher bulk water content but lacking water gradient), thus emphasising the importance of the hydration and structure of the CL surface.…”

Tear Film Dynamics between Low and High Contact Lens Dry Eye Disease Questionnaire (CLDEQ-8) Score with a Lehfilcon A Silicone Hydrogel Water Gradient Contact Lens: A Non-Invasive Methodology Approach

“…All materials were described in a previous study [22]. Only listed below: Clinical Platform (ICP) Ocular Surface Analyzer (OSA) from SBM System ® (Orbassano, Torino, Italy), Nonmydriatic infrared meibography digital fundus camera Cobra ® HD (Construzione Strumenti Oftalmici CSO ® , Firenze, Italy), Contact Lens Dry Eye Questionnaire 8 (CLDEQ-8) [13,14] and the Standard Patient Evaluation of Eye Dryness (SPEED).…”