Pre-operative disinfection of the vagina

Duignan, N. M.; Lowe, P.

doi:10.1093/jac/1.1.117

Cited by 18 publications

(8 citation statements)

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“…It is therefore not surprising that this antiseptic is now widely used in hospitals as a surgical scrub and for skin disinfection. It has also been recommended in the treatment of burns (Wynn-Williams and Monballiu, 1965) and varicose ulcers (Thorne and Fox, 1965), and as a shampoo (Dineen and Drusin, 1973) and vaginal disinfectant (Duignan and Lowe, 1975). Recently, a dry powder aerosol formulation has been shown in controlled trials to be effective in preventing postoperative wound infection (Gilmore et al, 1973;Gilmore and Martin, 1974;Gilmore and Sanderson, 1975a).…”

mentioning

confidence: 99%

Absence of bacterial resistance to povidone iodine.

Houang¹,

Gilmore²,

Reid³

et al. 1976

J Clin Pathol

103

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Povidone iodine is now being increasingly used in hospitals as an antiseptic. The possible habituation of bacteria to iodine was studied by serial passage of two strains of Pseudomonas aeruginosa, two strains of Escherichia coli, two strains of Klebsiella aerogenes, and one strain of Serratia marcescens in subinhibitory concentrations. After 20 passages, no significant change was observed in the minimal inhibitory concentration, minimal bactericidal concentration, and killing times between parent strains and 20th subcultures under standardized conditions.

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mentioning

confidence: 99%

Absence of bacterial resistance to povidone iodine.

Houang¹,

Gilmore²,

Reid³

et al. 1976

J Clin Pathol

103

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“…NOTES represents an endoscopic extension of this technique. Disinfection of the vagina through irrigation with antiseptic such as povidone-iodine is known to produce good bactericidal results with great reduction in positive vaginal bacterial cultures [26]. As a result, the transvaginal approach for NOTES procedures is the most reported route of access in current literature, with larger case series already published for procedures ranging from laparoscopic cholecystectomies [27, 28] to NOTES-assisted right hemicolectomies [29].…”

Section: Resultsmentioning

confidence: 99%

Disinfection of the Access Orifice in NOTES: Evaluation of the Evidence Base

Sodergren

Pucher

Clark

et al. 2011

Diagnostic and Therapeutic Endoscopy

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Introduction. Appropriate prevention of infection is a key area of research in natural orifice translumenal endoscopic surgery (NOTES), as identified by the Natural Orifice Surgery Consortium for Assessment and Research (NOSCAR). Methods. A review of the literature was conducted evaluating the evidence base for access orifice preparation/treatment in NOTES procedures in the context of infectious complications. Recommendations based on the Oxford Centre for Evidence-Based Medicine guidelines were made. Results. The most robust evidence includes several experimental randomised controlled trials assessing infectious complications in the transgastric approach to NOTES. Transvaginal procedures are long established for accessing the peritoneal cavity following disinfection with antiseptic. Only experimental case series for transcolonic and transvesical approaches are described. Conclusion. Grade C recommendation requiring no preoperative preparation can be made for the transgastric approach. Antiseptic irrigation is recommended for transvaginal (grade C) NOTES access, as is current practice. Further human trials need to be conducted to corroborate the current evidence base for transgastric closure. It is important that future trials are conducted in a methodologically robust fashion, with emphasis on clinical outcomes and standardisation of enterotomy closure and postoperative therapy.

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“…Solutions based on chlorhexidine gluconate, a bisbiguanide with disruptive effects on microbial cell membranes, but non‐toxic for human skin and squamous epithelium, have also been in use for many decades. These agents are effective in reducing the number of both aerobic and anaerobic bacteria in the vagina (12–15).…”

Section: Discussionmentioning

confidence: 99%