2001
DOI: 10.1053/ejso.2001.1199
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Pre-operative serum levels of sialyl Tn antigen predict liver metastasis and poor prognosis in patients with gastric cancer

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Cited by 23 publications
(21 citation statements)
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“…Our interest was to isolate the small subfraction of circulating O-glycoproteins with aberrant STn O-glycosylation, which are predicted to exist from studies with the CA72-4 assay (53, 54) and lectin arrays (55)(56)(57)(58). High levels of STn are detectable in sera of patients with different cancer types (59 -61) and this is associated with lower survival (62,63). We confirmed that STn O-glycoproteins are selectively found in gastric cancer patients.…”
Section: Discussionmentioning
confidence: 60%
“…Our interest was to isolate the small subfraction of circulating O-glycoproteins with aberrant STn O-glycosylation, which are predicted to exist from studies with the CA72-4 assay (53, 54) and lectin arrays (55)(56)(57)(58). High levels of STn are detectable in sera of patients with different cancer types (59 -61) and this is associated with lower survival (62,63). We confirmed that STn O-glycoproteins are selectively found in gastric cancer patients.…”
Section: Discussionmentioning
confidence: 60%
“…The 5-year survival rate for patients in the high STN group was significantly less than that of patients in the low STN group (44.8 vs. 75.1 %, P \ 0.05). Nakagoe et al [59] confirmed similar conclusions that high serum STN was an independent factor that predicted liver metastasis and a worse outcome in gastric cancer patients.…”
Section: Clinical Significance Of Serum Marker Monitoring During Chemmentioning
confidence: 54%
“…Four discussion points were evaluated for CEA, CA19-9, and CA72-4 from selected articles as follows: (1) positive rates, (2) clinicopathological significance, (3) prognostic impact, and (4) clinical impact during follow-up after surgery and/or during chemotherapy. Finally, we selected 10 other publications that focused only on AFP [51][52][53][54], CA125 [3,[55][56][57], and STN [58,59] (Fig. 1).…”
Section: Manuscript Selectionmentioning
confidence: 99%
“…66,67 The commonly used markers in gastric cancer are carcinoembryonic antigen (CEA) 68 and sialyl Lewis a antigen (CA19-9). 69 A high percentage of CEA-positive tumors are noted in differentiated gastric cancers. 70 The preoperative level of CEA is strongly correlated with clinical estimation of tumor mass and progression of the disease.…”
Section: Tumor Markersmentioning
confidence: 99%
“…84 Preoperative high serum levels of STN predict both liver metastasis and poor prognosis after a resection for gastric cancer. 85,86 Gastric cancer metastasized to the liver is found to overexpress HER2 at a signifi cantly higher incidence (65%) than primary gastric cancers (38%). 87 All these gastric cancer liver metastasis cell lines are highly sensitive to gefi tinib, a specifi c inhibitor of EGFR tyrosine kinase (Iressa) rather than anti-HER2 antibody trastuzumab (Herceptin), whereas most of the HER2 lowexpressing lines are not.…”
Section: Tumor Markersmentioning
confidence: 99%