Pre-oxidation induced in situ interface strengthening in biodegradable Zn/nano-SiC composites prepared by selective laser melting

Gao, Chengde; Yang, Meng; Peng, Shuping; Tan, Wei; Shuai, Cijun

doi:10.1016/j.jare.2021.09.014

Cited by 42 publications

(15 citation statements)

References 54 publications

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“…Cell viability is also an important indicator for evaluating the cytocompatibility of the scaffold [37][38][39]. To investigate the cells viability induced by the PLLA, PLLA/Fe 3 O 4 and PLLA/Fe 3 O 4 @SiO 2 scaffolds, the cells were strained with calcein AM.…”

Section: Cytocompatibilitymentioning

confidence: 99%

Construction of Magnetic Nanochains to Achieve Magnetic Energy Coupling in Scaffold

Shuai

Chen

et al. 2022

Preprint

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Background: Fe3O4 nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. Methods: In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe3O4 nanoparticles. In detail, multiple Fe3O4 nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO2), and consequently forming linear magnetic nanochains (Fe3O4@SiO2). The Fe3O4@SiO2 nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology.Results: The results show that the Fe3O4@SiO2 nanochains with unique core-shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe3O4@SiO2 nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe3O4@SiO2 scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe3O4 scaffolds. Conclusion: In short, the Fe3O4@SiO2 nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair.

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Section: Cytocompatibilitymentioning

confidence: 99%

Construction of Magnetic Nanochains to Achieve Magnetic Energy Coupling in Scaffold

Shuai

Chen

et al. 2022

Preprint

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“…In detail, the cell viability levels for M0 were 57% at day 1, 62% at day 3, and 70% at day 5, respectively, indicating relatively low cell viability. This was attributed to the fast degradation rate leading to increased pH, which was harmful to cell growth [40][41][42]. Regarding M30, the cell viability reached 62% at day 1, 75% at day 3, and 88% at day 5.…”

Section: Cytocompatibilitymentioning

confidence: 99%

Laser-Sintered Mg-Zn Supersaturated Solid Solution with High Corrosion Resistance

Wang

Yang

et al. 2021

Micromachines

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Solid solutions of Zn as an alloy element in Mg matrixes are expected to show improved corrosion resistance due to the electrode potential being positively shifted. In this study, a supersaturated solid solution of Mg-Zn alloy was achieved using mechanical alloying (MA) combined with laser sintering. In detail, supersaturated solid solution Mg-Zn powders were firstly prepared using MA, as it was able to break through the limit of phase diagram under the action of forced mechanical impact. Then, the alloyed Mg-Zn powders were shaped into parts using laser sintering, during which the limited liquid phase and short cooling time maintained the supersaturated solid solution. The Mg-Zn alloy derived from the as-milled powders for 30 h presented enhanced corrosion potential and consequently a reduced corrosion rate of 0.54 mm/year. Cell toxicity tests confirmed that the Mg-Zn solid solution possessed good cytocompatibility for potential clinical applications. This study offers a new strategy for fabricating Mg-Zn solid solutions using laser sintering with MA.

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“…Zinc (Zn) has attracted widespread attention in the field of biodegradable implant materials due to its suitable degradation rate and biocompatibility. − Unfortunately, the deficient mechanical strengths obstruct its application in clinical bone transplantation . Carbon nanotubes (CNTs) have superior strength, extreme high Young’s modulus, and a large aspect ratio .…”

Section: Introductionmentioning

confidence: 99%

Rivet-Inspired Modification of Carbon Nanotubes by In Situ-Reduced Ag Nanoparticles To Enhance the Strength and Ductility of Zn Implants

Shuai

Dong

Yang

et al. 2021

ACS Biomater. Sci. Eng.

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Zinc shows promise for bone repair applications, while its strength and ductility require to be improved. Carbon nanotubes (CNTs) are exceptional reinforcements due to their superior strength, ultrahigh Young’s modulus, and large aspect ratio. However, their strong agglomeration and weak interfacial bonding with the matrix are key bottleneck problems restricting the reinforcing effect. In this study, Ag nanoparticles were in situ reduced on CNTs and then the CNT@Ag powders were used to prepare Zn-CNT@Ag implants by laser powder bed fusion. Results showed that Ag reacted with Zn to form a “knot”-like AgZn3 phase. It had the same lattice structure (HCP) with Zn, which indicated a good lattice matching with the matrix, thus improving the dispersion of CNTs. More significantly, the knot played a “rivet” role and enhanced the load transfer capacity, which advantaged the CNT strengthening effects by assisting in transferring the load. Moreover, it enhanced the heterogeneous nucleation effects during solidification, which weakened the texture strength of the matrix and thus increased the ductility by improving the sliding capacity. The compressive yield strength, ultimate tensile strength, and elongation of the Zn-CNT@Ag implant were increased by 22, 26, and 17% in comparison to Zn-CNTs. Moreover, the Zn-CNT@Ag implant exhibited favorable antibacterial activity with a bacterial inhibition rate of 87.79%. Additionally, it also exhibited a suitable degradation rate and acceptable biocompatibility.

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Pre-oxidation induced in situ interface strengthening in biodegradable Zn/nano-SiC composites prepared by selective laser melting

Cited by 42 publications

References 54 publications

Construction of Magnetic Nanochains to Achieve Magnetic Energy Coupling in Scaffold

Construction of Magnetic Nanochains to Achieve Magnetic Energy Coupling in Scaffold

Laser-Sintered Mg-Zn Supersaturated Solid Solution with High Corrosion Resistance

Rivet-Inspired Modification of Carbon Nanotubes by In Situ-Reduced Ag Nanoparticles To Enhance the Strength and Ductility of Zn Implants

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