Pre/post-closure assessment of groundwater pharmaceutical fate in a wastewater-facility-impacted stream reach

Bradley, Paul M.; Barber, Larry B.; Clark, Jimmy M.; Duris, Joseph W.; Foreman, William T.; Furlong, Edward T.; Givens, Carrie E.; Hubbard, L.E.; Hutchinson, Kasey J.; Journey, Celeste A.; Keefe, Steffanie H.; Kolpin, Dana W.

doi:10.1016/j.scitotenv.2016.06.104

Cited by 24 publications

(16 citation statements)

References 61 publications

(75 reference statements)

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“…Differences (permutation N = 9999 probability of being the same = 0.0001) in the centroids of cumulative median detections and concentrations were observed between sites with (detections median: 3, IQR: 2-9; cumulative concentrations median: 62 ng/L; IQR: 20-405 ng/L) and without permitted wastewater discharges (detections median: 1, IQR: 0-3; cumulative concentrations median: 11 ng/L; IQR: 0-55 ng/L). These results are consistent with the documented importance of WWTP discharges as pharmaceutical-contaminant sources [84,85] and the substantial pharmaceutical-contaminant reductions in urban-area wadeable streams following WWTP-treatment upgrades [84,85] or WWTP closures [86,87].…”

Section: Pharmaceutical Mixtures Were Common In All Regionssupporting

confidence: 84%

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

et al. 2020

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Human-use pharmaceuticals in urban streams link aquatic-ecosystem health to human health. Pharmaceutical mixtures have been widely reported in larger streams due to historical emphasis on wastewater-treatment plant (WWTP) sources, with limited investigation of pharmaceutical exposures and potential effects in smaller headwater streams. In 2014-2017, the United States Geological Survey measured 111 pharmaceutical compounds in 308 headwater streams (261 urban-gradient sites sampled 3-5 times, 47 putative lowimpact sites sampled once) in 4 regions across the US. Simultaneous exposures to multiple pharmaceutical compounds (pharmaceutical mixtures) were observed in 91% of streams (248 urban-gradient, 32 low-impact), with 88 analytes detected across all sites and cumulative maximum concentrations up to 36,142 ng/L per site. Cumulative detections and concentrations correlated to urban land use and presence/absence of permitted WWTP discharges, but pharmaceutical mixtures also were common in the 75% of sampled streams without WWTP. Cumulative exposure-activity ratios (EAR) indicated widespread transient exposures with high probability of molecular effects to vertebrates. Considering the potential individual and interactive effects of the detected pharmaceuticals and the recognized analytical underestimation of the pharmaceutical-contaminant (unassessed parent compounds, metabolites, degradates) space, these results demonstrate a nationwide environmental concern and the need for watershed-scale mitigation of in-stream pharmaceutical contamination.

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Section: Pharmaceutical Mixtures Were Common In All Regionssupporting

confidence: 84%

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

et al. 2020

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“…Despite the relatively minor impacts in terms of the total mass load to larger water bodies (e.g., high-flow rivers), continuous high pharmaceutical loading to small, local streams can generate substantially elevated exposure concentrations due to limited dilution and potentially impact biota. Furthermore, groundwater recharge in the temperate-region, losing-reach stream (due to effluent influx) can cause pharmaceuticals to also be transported along subsurface pathways into adjacent aquifers and could pose potential risks to drinking water sources . Our work also demonstrates the potential benefits of treated wastewater effluent in a small stream, such as maintaining the streamflow during baseflow/drought conditions and modulating water temperature fluctuations (i.e., cooling effect in the summer and warming effect in the winter).…”

Section: Results and Discussionmentioning

confidence: 99%

“…There is a paucity of knowledge concerning dynamic pharmaceutical concentrations and compositions in streams, despite the potential for drug–drug interactions (e.g., synergistic, antagonistic responses) in complex exposure mixtures. Mounting evidence suggests that pharmaceuticals can have deleterious effects on aquatic species at environmentally relevant concentrations (i.e., <1 μg/L). − For example, pharmaceuticals can cause behavior changes, endocrine disruption, and reduced size and fecundity in fish. ,− Substantial transport of pharmaceuticals with varied attenuation (e.g., half-lives from hours to days) has been documented in effluent-impacted streams. ,, Composition of evolving pharmaceutical mixtures may depend not only on the input variability (e.g., different sources, seasonal usage) but also on differential in-stream attenuation processes of individual compounds; , for example, biotransformation and sorption can differ substantially. , Due to constant source inputs, many pharmaceuticals are considered “pseudo-persistent”, but input variability and mixture dynamics are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Spatiotemporal Dynamics of Pharmaceuticals in a Temperate-Region Wastewater Effluent-Dominated Stream: Variable Inputs and Differential Attenuation Yield Evolving Complex Exposure Mixtures

Zhi

Kolpin

Klaper

et al. 2020

Environ. Sci. Technol.

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Effluent-dominated streams are becoming increasingly common in temperate regions and generate complex pharmaceutical mixture exposure conditions that may impact aquatic organisms via drug–drug interactions. Here, we quantified spatiotemporal pharmaceutical exposure concentrations and composition mixture dynamics during baseflow conditions at four sites in a temperate-region effluent-dominated stream (upstream, at, and progressively downstream from effluent discharge). Samples were analyzed monthly for 1 year for 109 pharmaceuticals/degradates using a comprehensive U.S. Geological Survey analytical method and biweekly for 2 years focused on 14 most common pharmaceuticals/degradates. We observed a strong chemical gradient with pharmaceuticals only sporadically detected upstream from the effluent. Seventy-four individual pharmaceuticals/degradates were detected, spanning 5 orders of magnitude from 0.28 to 13 500 ng/L, with 38 compounds detected in >50% of samples. “Biweekly” compounds represented 77 ± 8% of the overall pharmaceutical concentration. The antidiabetic drug metformin consistently had the highest concentration with limited in-stream attenuation. The antihistamine drug fexofenadine inputs were greater during warm- than cool-season conditions but also attenuated faster. Differential attenuation of individual pharmaceuticals (i.e., high = citalopram; low = metformin) contributed to complex mixture evolution along the stream reach. This research demonstrates that variable inputs over multiple years and differential in-stream attenuation of individual compounds generate evolving complex mixture exposure conditions for biota, with implications for interactive effects.

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“…Based on this fact, that is the reason why simulation, prediction and monitoring of groundwater parameters using Galerkin's Finite Element Method were used to simulate the mass transport of groundwater parameters concentration within Trans-Amadi area in Port Harcourt upon a given distance. The pollution is increasing and resultantly groundwater is contaminating (Adrover et al, 2017;Bishop et al, 2017;Bradley et al, 2016;Bricker et al, 2017;Fackrell et al, 2016;Fisher et al, 2016;K'Oreje et al, 2016;LaGro et al, 2017;Lamastra et al, 2016;Ma et al, 2016a;Ma et al, 2016b;Richardson et al, 2017;Robertson et al, 2016;Sanciolo and Gray, 2017;Yan et al, 2017a;Yan et al, 2017b). The integration of finite element techniques is proved to efficient technique for evaluation of trans-Amadi groundwater parameters and could possibly be used for the monitoring of ground water to evaluate the effect of pollution on water quality (Alaboodi and Hussain, 2017;Awais et al, 2017;Boffi and Stenberg, 2017;Hedayat et al, 2017;Jacques et al, 2017;Jeong et al, 2017;Keith et al, 2017;Lee et al, 2017;Liu et al, 2017;Lostado-Lorza et al, 2017;Mironova et al, 2017).…”

Section: Prediction Of Groundwater Parameters Interaction Bymentioning

confidence: 99%

Development and evaluation of trans-Amadi groundwater parameters: The integration of finite element techniques

Int¹

2019

Preprint

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Mathematical model was developed and evaluated to monitor and predict the groundwater characteristics of Trans-amadi region in Port Harcourt City. In this research three major components were considered such as chloride, total iron and nitrate concentration as well as the polynomial expression on the behavious on the concentration of each component was determined in terms of the equation of the best fit as well as the square root of the curve. The relationship between nitrate and distance traveled by Nitrate concentration by the model is given as Pc = 0.003x2 - 0.451x + 14.91with coefficient of determination, R² = 0.947, Chloride given as Pc = 0.000x2 - 0.071x + 2.343, R² = 0.951while that of Total Iron is given as Pc = 2E-05x2 - 0.003x + 0.110, R² = 0.930. All these show a strong relationship as established by Polynomial Regression Model. The finite element techniques are found useful in monitoring, predicting and simulating groundwater characteristics of Trans-amadi as well as the prediction on the variation on the parameters of groundwater with variation in time.

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Pre/post-closure assessment of groundwater pharmaceutical fate in a wastewater-facility-impacted stream reach

Cited by 24 publications

References 61 publications

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

Occurrence and Spatiotemporal Dynamics of Pharmaceuticals in a Temperate-Region Wastewater Effluent-Dominated Stream: Variable Inputs and Differential Attenuation Yield Evolving Complex Exposure Mixtures

Development and evaluation of trans-Amadi groundwater parameters: The integration of finite element techniques

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