Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats

Chen, Wanchao; Wu, Di; Jin, Yueling; Li, Qiaozhen; Liu, Yanfang; Qiao, Xuxin; Zhang, Jingsong; Dong, Guochao; Li, Zhengpeng; Li, Tingting; Yang, Yan

doi:10.1016/j.ijbiomac.2020.05.163

Cited by 34 publications

(24 citation statements)

References 41 publications

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“…Increased production of endogenous PGs may result in increased gastric mucosal resistance against harmful agents, such as ethanol [51]. Particularly, PGs E 2 and I 2 amplify the secretion of bicarbonate and mucus contributing to the balance of gastric pH, maintain the blood flow of the gastric mucosa and coordinate the defense, renewal, and repair of the mucosal epithelial cells [45,70,[93][94][95]. In addition, PGE 2 via the EP receptor can inhibit acid secretion and histamine release by parietal cells and enterochromaffin-like cells, respectively [95].…”

Section: Ability To Repair the Mucosamentioning

confidence: 99%

Gastroprotective Mechanisms

Lima¹,

Lima²,

Souza³

et al. 2022

Peptic Ulcer Disease - What's New?

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Gastric ulcer (GU), a common type of peptic ulcer, results from an imbalance in the action of protective and aggressive agents. Gastroprotective mechanisms are mucus layer, gastric epithelium, gastric blood flow, gastric neurons, mucosal repair capacity, and immune system. Thus, the aim of this chapter was to provide an update on gastroprotective mechanisms. It was carried out through searches in PubMed covering the years 2016–2021 using several keywords. This survey resulted in 428 articles, of which 110 were cited in this chapter. It was reviewed the status of gastroprotective mechanisms and highlighted that mucins can act as a filter; gastric epithelial defenses are composed of the cell barrier, stem cells, and sensors on the mucosal surface; nitric oxide (NO) and hydrogen sulfide (H2S) act for gastric blood flow homeostasis (GBF); the main effector neurons in the gastric mucosa are cholinergic, nitrergic and VIPergic, and oxytocin can activate neurons; repair of the gastric mucosa requires complex biological responses; the immune system regulates the entry of antigens and pathogens. The main knowledge about gastroprotective mechanisms remains unchanged. However, we conclude that there has been progressing in this area.

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Section: Ability To Repair the Mucosamentioning

confidence: 99%

Gastroprotective Mechanisms

Lima¹,

Lima²,

Souza³

et al. 2022

Peptic Ulcer Disease - What's New?

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“…A new skeleton phenolic compound was isolated from fruiting bodies of H. erinaceus by Li et al [16], named Erinacene D. In addition to terpenoids and phenolics compounds, H. erinaceus was rich in steroids, six new (erinarols A-F), and five known ergostane-type sterol fatty acid esters were isolated from the fruiting bodies of H. erinaceus; erinarols A and B significantly activated the transcriptional activity of PPARs, PPARα, and PPARc [17]. Previous pharmacological studies showed that H. erinaceus had many pharmacological activities, such as regulating immunity [18,19], neuroprotection [20,21], antidepressant [22,23], antioxidant [24], antitumor [25], antihyperglycemic [26], and antihyperlipidemic properties [27], and protecting gastric mucosa [28,29].…”

Section: Introductionmentioning

confidence: 99%

Rapid Identification of Chemical Constituents in Hericium erinaceus Based on LC-MS/MS Metabolomics

Yang

Wang

Feng³

et al. 2021

Journal of Food Quality

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Hericium erinaceus is a precious edible and medicinal fungus with high nutritional value. It has many functions, such as enhancing immunity, antitumor antioxidation, antihyperglycemic, antihyperlipidemic, and protecting gastric mucosa. However, there are few researches about the H. erinaceus compounds. In this paper, ultraperformance liquid chromatography tandem high-resolution mass spectrometry (UPLC-Q-exactive-MS/MS) was used to isolate and identify the compounds in H. erinaceus. 102 compounds were identified in H. erinaceus by comparing with standard databases such as MZVault, MZCloud, and BGI Library (self-built standard Library by BGI Co., Ltd), including flavonoids, terpenoids, phenolic acids, phenylpropanoids, steroids, organic acids, and amino acids.

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“…A gastric ulcer is a peptic ulcer that occurs in the corners of the stomach, gastric antrum, cardia, and hiatal hernia ( 1 ). It is one of the most common diseases worldwide.…”

Section: Introductionmentioning

confidence: 99%

Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury

et al. 2021

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In this study, deer suet fat was used as a raw material to study the effects of aqueous enzymatic extraction of deer oil on its components, followed by studies into the potential protective activity, and related molecular mechanisms of deer oil on ethanol-induced acute gastric mucosal injury in rats. The results show that aqueous enzymatic extraction of deer oil not only has a high extraction yield and has a small effect on the content of active ingredients. Deer oil can reduce total stomach injury. Without affecting the blood lipid level, it can reduce the oxidative stress, which is manifested by reducing the content of myeloperoxidase (MPO) and enhancing the activity level of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). It also enhances the expression of defense factors prostaglandin (E2), epidermal growth factor (EGF), and somatostatin (SS), it inhibits apoptosis evidenced by the enhanced of Bcl-2 and decreased expression of cleavage of caspase-3 and Bax. At the same time, it reduces inflammation, which is manifested by reducing the expression of IL-1β, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) gastric tissue pro-inflammatory cytokines, and enhancing the expression of anti-inflammatory factors IL-4 and IL-10, and inhibiting the mitogen-activated protein kinase/nuclear factor kappa B (MAPK/NF-κB) signaling pathway in gastric tissue.

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Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats

Cited by 34 publications

References 41 publications

Gastroprotective Mechanisms

Gastroprotective Mechanisms

Rapid Identification of Chemical Constituents in Hericium erinaceus Based on LC-MS/MS Metabolomics

Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury

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