This paper presents some features of the ionospheric response observed in equatorial and mid-latitudes region to two strong geomagnetic storms, occurring during Oct. 19-23, 2001 and May 13-17, 2005 and to understand the phenomena of pre-storm that lead to very intense geomagnetic storms. The result point to the fact that pre-storm phenomena that leads to intense ionospheric storm are; large southward turning of interplanetary magnetic field Bz, high electric field, increase in flow speed stream, increase in proton number density, high pressure ram and high plasma beta. The magnitude of Bz turning into southward direction from northward highly depends upon the severity of the storm and the variation in F2 layer parameter at the time of geomagnetic storm are strongly dependent upon the storm intensity. A detailed analysis of the responses of the ionosphere shows that during the storm periods, foF2 values depleted simultaneously both in the equatorial and mid latitude. Observation also shows that low to moderate variations in ionospheric F2 at the pre-storm period may signal the upcoming of large ionospheric disturbances at the main phase. The ionospheric F2response for low and mid latitude does not show any significant differences during the storm main phase and the prestorm period. The ionospheric response during the pre-storm period is thought very puzzling. The period is observed to be depleted throughout with low-moderate effect across all the stations in the low and mid latitude.