Pre-surgical management of primary leiomyosarcoma of the bone

Abstract

"Leiomyosarcoma is a rare type of smooth muscle cell tumor, with an incidence of 7-10% compared to other types of sarcomas. It develops primarily in the retroperitoneal cavity, the genital tract and extremities. Leiomyosarcoma can also affect the bone, either as a primary tumor or as metastasis. Primary osseus leiomyosarcoma is a rare finding in patients with radiologically identified osteolytic lesions having an incidence of <1% of total primary bone tumors.Due to its low incidence patients with primary osseous leiomyosarcoma are never diagnosed before immunohistochemical analysis and case management is difficult because of the lack of specific indications pertaining to primary osseus leiomyosarcoma. Data on age specific incidence is scarce but there seems to be a tendency towards a higher incidence with advanced age. The purpose of this work is to discuss the complete management of primary osseus leiomyosarcomas based on interdisciplinary medical teams’ indications in a Romanian hospital setting"

Development and Validation of the Bone Tumor Surgery Complexity Score

“…Our findings indicate that the BT-SCS, encompassing patient characteristics, tumor biology, and surgical parameters, offers a nuanced and multi-dimensional approach to understanding surgical case complexity. By systematically analyzing 501 cases, we demonstrated the practicality and relevance of the BT-SCS in categorizing surgical complexity, which is crucial for optimized surgical planning and resource allocation in bone tumor treatments, as supported by current research in the field [11,26].…”