Pre-β-HDL formation relates to high-normal free thyroxine in type 2 diabetes mellitus

Tienhoven-Wind, Lynnda J. N. van; Perton, Frank G.; Dullaart, Robin

doi:10.1016/j.clinbiochem.2015.08.024

Cited by 7 publications

(7 citation statements)

References 34 publications

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“…If this also holds true for the human hypothyroid condition, then it seems plausible that changes in pre β-HDL, a lipid-poor nascent HDL particle that interacts with the ABCA1 receptor, play a role in hypothyroidism-induced CEC impairment. In this regard, it is noteworthy that pre-β-HDL formation correlates positively with high-normal fT4 levels in humans (40). Furthermore, we observed a shift toward larger, more cholesterol-containing HDL particles during hypothyroidism as expected (7,8).…”

Section: Discussionsupporting

confidence: 72%

HDL Cholesterol Efflux Capacity is Impaired in Severe Short-Term Hypothyroidism Despite Increased HDL Cholesterol

Boom

Jia

Lefrandt

et al. 2020

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Severe hypothyroidism has profound effects on lipoprotein metabolism including high-density lipoprotein (HDL) cholesterol elevations but effects on HDL function metrics are unknown. Objective To determine the impact of severe short-term hypothyroidism on HDL particle characteristics, HDL cholesterol efflux capacity (CEC), and HDL antioxidative capacity. Design Observational study with variables measured during severe short-term hypothyroidism (median TSH 81 mU/L) and after 20 weeks of thyroid hormone supplementation (median TSH 0.03 mU/L) (Netherlands Trial Registry ID 7228). Setting University hospital setting in The Netherlands. Patients Seventeen patients who had undergone a total thyroidectomy for differentiated thyroid carcinoma. Main outcome measures HDL particle characteristics (nuclear magnetic resonance spectrometry), CEC (human THP-1-derived macrophage foam cells and apolipoprotein B-depleted plasma), and HDL anti-oxidative capacity (inhibition of low-density lipoprotein oxidation). Results During hypothyroidism plasma total cholesterol, HDL cholesterol and apolipoprotein A-I were increased (P ≤ 0.001). HDL particle concentration was unchanged, but there was a shift in HDL subclasses toward larger HDL particles (P < 0.001). CEC was decreased (P = 0.035), also when corrected for HDL cholesterol (P < 0.001) or HDL particle concentration (P = 0.011). HDL antioxidative capacity did not change. Conclusion During severe short-term hypothyroidism CEC, an important antiatherogenic metric of HDL function, is impaired. HDL cholesterol and larger HDL particles are increased but HDL particle concentration is unchanged. Combined, these findings suggest that HDL quality and quantity are not improved, reflecting dysfunctional HDL in hypothyroidism.

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Section: Discussionsupporting

confidence: 72%

HDL Cholesterol Efflux Capacity is Impaired in Severe Short-Term Hypothyroidism Despite Increased HDL Cholesterol

Boom

Jia

Lefrandt

et al. 2020

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Preβ1-HDL is considered to be an atherogenic lipoprotein; although Lynnda et al found that preβ-HDL formation was affected by high-normal free thyroxine in type 2 diabetes mellitus [28]. The mechanisms by which it contributes to atherosclerosis remain widely unknown.…”

Section: Discussionmentioning

confidence: 99%

Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease

Niu

et al. 2017

Lipids Health Dis

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BackgroundPreβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of preβ1-HDL with extent of CAD are debatable.MethodsPreβ1-HDL and CETP levels were measured by enzymed-linked immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects. The correlation analyses, multiple linear regression analyses and logistic regression analyses were performed, respectively.ResultsThe preβ1-HDL and CETP levels in ACS patients were significantly higher than those in SCAD patients and both of them were higher than controls’. Preβ1-HDL levels were positively associated with CETP (R = 0.348, P = 0.000), the diameter of stenosis (R = 0.253, P = 0.005), the number of vessel disease (R = 0.274, P = 0.002) and Gensini score (R = 0.227, P = 0.009) in CAD patients. Stepwise multiple linear regression analyses showed that CETP was one of the determinants of preβ1-HDL levels. Logistic regression analysis revealed that elevated preβ1-HDL and CETP were potential risk factors for both ACS and SCAD.ConclusionThe elevated preβ1-HDL levels may change with CETP concentrations in CAD patients and were related to the presence and severity of CAD.

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“…HDL synthesis decreases in hypothyroidism. A study has documented a positive relationship between FT4 and plasma pre-β-HDL formation in type 2 diabetes mellitus patients [137]. TH strongly induces ApoA1 gene and protein expression [138],…”

Section: Thyroid Hormone Affects Hdl Levelsmentioning

confidence: 99%

Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism

Liu

Peng

2022

Endocrine Connections

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Hypothyroidism is often associated with elevated serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides. Thyroid hormone (TH) affects the production, clearance and transformation of cholesterol, but current research shows that thyroid-stimulating hormone (TSH) also participates in lipid metabolism independently of TH. Therefore, the mechanism of hypothyroidism-related dyslipidemia is associated with the decrease of TH and the increase of TSH levels. Some newly identified regulatory factors, such as proprotein convertase subtilisin/kexin type 9 (PCSK9), angiogenin-like proteins (ANGPTL), and fibroblast growth factors (FGF) are the underlying causes of dyslipidemia in hypothyroidism. High-density lipoprotein (HDL) serum concentration changes were not consistent, and its function was reportedly impaired. The current review focuses on the updated understanding of the mechanism of hypothyroidism-related dyslipidemia.

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Pre-β-HDL formation relates to high-normal free thyroxine in type 2 diabetes mellitus

Cited by 7 publications

References 34 publications

HDL Cholesterol Efflux Capacity is Impaired in Severe Short-Term Hypothyroidism Despite Increased HDL Cholesterol

HDL Cholesterol Efflux Capacity is Impaired in Severe Short-Term Hypothyroidism Despite Increased HDL Cholesterol

Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease

Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism

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